Argatroban (Mixture of Diastereomers)

Basic Information

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CAS Number

74863-84-6

Molecular Formula

C23H36N6O5S

Molecular Weight

508.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

188-1890C

SMILES

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C[C@@H]1CCN([C@H](C1)C(=O)O)C(=O)[C@H](CCCNC(=N)N)NS(=O)(=O)c2cccc3CC(C)CNc23

InChI

InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1

InChIKey

KXNPVXPOPUZYGB-IOVMHBDKSA-N

LogP

0.9125700000000045

Topological Polar Surface Area

177.70999999999998 Å²

Hydrogen Bond Donor/Acceptor

7 / 11

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

Synonyms & References

English

Argatroban
(2R,4R)-4-Methyl-1-[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
(2r,4r)-4-methyl-1-[n-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl]-2-piperidinecarboxylic acid
GN1600
(2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Argatroban Monohydrate
2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-
Argatroban anhydrous
Argatroban(mixture of isomers)
Argipidine
Argatroban iMpurity
(2R,4R)-4-methyl-1-(((3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-L-arginyl)piperidine-2-carboxylic acid

MDL Number

MFCD00866789

Customs Code

2935009090

FAQ

What is Argatroban (CAS: 74863-84-6)?

Argatroban (CAS: 74863-84-6) is a synthetic anticoagulant used primarily in medical settings. It functions as a direct thrombin inhibitor and is available as a mixture of diastereomers. The compound has a molecular formula of C17H24N2O5S and is known for its ability to prevent blood clot formation by blocking the activity of thrombin. It is commonly administered intravenously.

What are the main uses of Argatroban (CAS: 74863-84-6)?

Argatroban (CAS: 74863-84-6) is mainly used in pharmaceuticals as an anticoagulant, particularly in patients with heparin-induced thrombocytopenia. It is also utilized in research for studying blood coagulation mechanisms and in clinical trials for developing new antithrombotic therapies. Its application extends to preventing thrombosis in various medical procedures.

Is Argatroban (CAS: 74863-84-6) safe?

Argatroban (CAS: 74863-84-6) is generally considered safe when used under medical supervision. However, it requires caution due to potential side effects such as bleeding and allergic reactions. Safety protocols include proper handling, monitoring of patients, and adherence to guidelines to minimize risks. It is approved for therapeutic use by regulatory bodies like the FDA.

How should Argatroban (CAS: 74863-84-6) be stored?

Argatroban (CAS: 74863-84-6) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to prevent moisture absorption. The recommended storage temperature is between 2°C and 8°C, and it should be protected from light to maintain its stability and efficacy over time.