2-Methoxybenzohydrazide

Basic Information

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CAS Number

7466-54-8

Molecular Formula

C8H10N2O2

Molecular Weight

166.18 g/mol

Basic Physical Properties

Melting Point

78-85°C

Boiling Point

294.38°C (rough estimate)

Density

1.2265 (rough estimate)

Water Solubility

Slightly soluble in water.

Refractive Index

1.6180 (estimate)

SMILES

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COC1=CC=CC=C1C(=O)NN

InChI

InChI=1S/C8H10N2O2/c1-12-7-5-3-2-4-6(7)8(11)10-9/h2-5H,9H2,1H3,(H,10,11)

InChIKey

QMGXWNSSMGAHCA-UHFFFAOYSA-N

LogP

0.29870000000000013

Topological Polar Surface Area

64.35 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

161

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

7466-54-8
o-Methoxybenzoylhydrazine
o-ANISIC ACID, HYDRAZIDE
2-Methoxybenzoic acid hydrazide
Benzoic acid, 2-methoxy-, hydrazide
F1724-0145
CHEMBL3237776
BRN 2208367
o-Anisohydrazide
FT-0612819
NSC-402658
A838189
o-Methoxybenzoic acid hydrazide
SY061614
Oprea1_317212
Benzoic acid, o-methoxy-, hydrazide
O-Anisic acid-,hydrazide
CS-W003975
EINECS 231-260-5
2-Methoxybenzhydrazide
UNII-19I9PY8G1D
19I9PY8G1D
Q27252107
NSC402658
NS00037645
o-Methoxybenzoylhydrazide
o-Methoxybenzhydrazide
WLN: ZMVR BO1
O-Anisic acid,hydrazide
Z57318022
2-Methoxybenzoyl hydrazide

MDL Number

MFCD00014755

Customs Code

2928000090

FAQ

What are the physical and chemical properties of 2-Methoxybenzohydrazide (CAS: 7466-54-8)?

2-Methoxybenzohydrazide (CAS: 7466-54-8) is a white crystalline solid with a molecular weight of approximately 186.18 g/mol. It has a pKa of about 8.4 and is slightly soluble in water. It exhibits good reactivity in amide and hydrazide reactions, making it useful in various synthetic applications. The compound is highly stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is 2-Methoxybenzohydrazide (CAS: 7466-54-8) typically synthesized?

2-Methoxybenzohydrazide (CAS: 7466-54-8) is commonly synthesized by the condensation of 2-methoxybenzohydrazine with an appropriate aldehyde or ketone in the presence of a catalytic amount of a suitable acid or base. This reaction is typically carried out in a solvent like ethanol or methanol at room temperature. The yield and selectivity can be optimized by using specific catalysts and reaction conditions.

What industries use 2-Methoxybenzohydrazide (CAS: 7466-54-8)?

2-Methoxybenzohydrazide (CAS: 7466-54-8) is primarily used in the pharmaceutical industry for the synthesis of intermediates and in the sensor industry for developing gas sensors. It also has applications in the polymer industry for the modification of polymer materials and in the semiconductor industry for the production of certain electronic materials.

What precautions should be taken when handling 2-Methoxybenzohydrazide (CAS: 7466-54-8)?

When handling 2-Methoxybenzohydrazide (CAS: 7466-54-8), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using appropriate spill kits and personal protective equipment. The Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) should be consulted for detailed safety information.