N-Methyl-N-(trimethylsilyl)acetamide

Basic Information

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CAS Number

7449-74-3

Molecular Formula

C6H15NOSi

Molecular Weight

145.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Physical Properties

Boiling Point

154°C

Density

0.904 g/mL at 20 °C

Refractive Index

n20/D 1.439

Vapor Pressure

6.4±0.3 mmHg at 25°C

SMILES

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CC(=O)N(C)[Si](C)(C)C

InChI

InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3

InChIKey

QHUOBLDKFGCVCG-UHFFFAOYSA-N

LogP

1.2995999999999999

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

117

Safety Information

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GHS Hazard Pictograms

H226

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

Hazard Class

Class 3 Class 3

Sensitiveness

Moisture Sensitive

Synonyms & References

English

M0536
7449-74-3
QHUOBLDKFGCVCG-UHFFFAOYSA-
W0IWF6UKW5
AMY3269
InChI=1/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
D91352
SY049706
EINECS 231-217-0
Acetamide, N-methyl-N-(trimethylsilyl)-
N-Methyl-N-(trimethylsilyl)acetamide
N-Methyl-N-TMS-acetamide
AKOS006229818
FT-0763229
DTXSID0064707
CS-0179366
N-Trimethylsilyl-N-methylacetamide
NSC-142435
MFCD00040758
N-Methylacetamide, TMS derivative
NS00047387
N-trimethylsilyl-N'-methylacetamide
N-Methyl-N-trimethylsilylacetamide, for GC derivatization, >=97.0% (GC)
UNII-W0IWF6UKW5
NSC142435
FS-4239
N-Methyl-N-trimethylsilyacetamide
NSC 142435
SCHEMBL537585
N-Methyl-N-trimethylsilylacetamide
N-methyl-N-(trimethylsilyl)acetamide

MDL Number

MFCD00040758

FAQ

What are the physical and chemical properties of N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3)?

N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3) is a colorless, viscous liquid at room temperature. It has a molecular weight of approximately 154.26 g/mol and is highly soluble in organic solvents like dichloromethane and acetone. This compound is reactive and can act as an acylating agent in organic synthesis, particularly useful for protecting acyl groups.

How is N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3) typically synthesized?

N-Methyl-N-(trimethylsilyl)acetamide can be synthesized by reacting acetic anhydride with trimethylsilyl chloride in anhydrous conditions. The reaction is catalyzed by a Lewis acid like aluminum chloride and proceeds with high selectivity and yield, typically around 90%. The reaction is exothermic and should be carried out at low temperature and under inert atmosphere.

What industries use N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3)?

N-Methyl-N-(trimethylsilyl)acetamide is widely used in the pharmaceutical, polymer, and semiconductor industries. In pharmaceuticals, it serves as a protective group reagent in synthetic chemistry. In polymers, it is used as a modifier. In semiconductors, it is employed in the fabrication of thin films and as a component in various chemical vapor deposition processes.

What precautions should be taken when handling N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3)?

When handling N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and goggles. The compound should be stored in a cool, dry place away from oxidizers. In case of spill, use appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.