Compound Q&A
How is N-Methyl-N-(trimethylsilyl)acetamide (CAS: 7449-74-3) typically synthesized?
Answer
N-Methyl-N-(trimethylsilyl)acetamide can be synthesized by reacting acetic anhydride with trimethylsilyl chloride in anhydrous conditions. The reaction is catalyzed by a Lewis acid like aluminum chloride and proceeds with high selectivity and yield, typically around 90%. The reaction is exothermic and should be carried out at low temperature and under inert atmosphere.
About
CAS No
7449-74-3
English Name
N-Methyl-N-(trimethylsilyl)acetamide
Molecular Formula
C6H15NOSi
Molecular Weight
145.28 g/mol
SMILES
CC(=O)N(C)[Si](C)(C)C
InChIKey
QHUOBLDKFGCVCG-UHFFFAOYSA-N
Last Updated: 2025-10-31 17:33
