5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)

Basic Information

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CAS Number

74381-53-6

Molecular Formula

C61H88N16O14

Molecular Weight

1251.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

150-155°C

Boiling Point

1720.5°C at 760 mmHg

Density

1.44

Flash Point

994.3°C

Refractive Index

1.681

SMILES

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CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O

InChI

InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1

InChIKey

RGLRXNKKBLIBQS-XNHQSDQCSA-N

LogP

-0.6576300000000126

Topological Polar Surface Area

435.10999999999996 Å²

Hydrogen Bond Donor/Acceptor

16 / 29

Complexity

2420

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

des-Gly10-[D-Leu6]-LH-RH ethylamide
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide--acetic acid (1/1)
Abbott 43818
88793-81-1
Leuprolide acetate [USAN:USP]
Abbott-43818
SMR000058945
74381-53-6
LEUPRORELIN ACETATE [WHO-DD]
TAP-144
Fensolvi
AKOS015895632
Uno-Enantone
LUPRON DEPOT-4
A829746
UNII-37JNS02E7V
CS-1434
Leuprolide acetate [USAN]
Lucrin Depot
CAS-74381-53-6
Procren
ELIGARD KIT
Leuplin depot
MFCD00072080
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tryosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate
Leuprolide Acetate (53714-56-0 free base)
LEUP
Prostap
37JNS02E7V
Onectyl
LUTRATE DEPOT KIT

MDL Number

MFCD00072080

FAQ

What is 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (CAS: 74381-53-6)?

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate is a complex synthetic peptide. It is an amino acid derivative with a specific sequence that includes various types of amino acids such as proline, histidine, tryptophan, serine, tyrosine, leucine, and arginine, along with a N-ethyl-L-proline side chain and an acetate moiety. This compound is highly hydrophilic and has potential applications in medicinal chemistry and pharmacology.

What are the main uses of 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (CAS: 74381-53-6)?

This peptide is primarily used in research, particularly in medicinal chemistry and pharmacology. It serves as a model compound for studying biophysical properties and potential therapeutic applications. Due to its complex structure, it may also be used in the development of new drugs and as a tool in protein structure studies.

Is 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (CAS: 74381-53-6) safe?

The safety of 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate depends on the context of its use. It is generally considered safe for research purposes when handled with appropriate precautions. However, it should be stored under appropriate conditions and handled with gloves and protective eyewear to prevent skin and eye contact. It is not considered toxic but can irritate the skin and eyes. Always follow safety guidelines and consult the material safety data sheet (MSDS) for detailed information.

How should 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (CAS: 74381-53-6) be stored?

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate should be stored in a cool, dry place away from direct sunlight and heat sources. It is recommended to store the compound in a tightly sealed container to protect it from moisture and degradation. Maintain a temperature not exceeding 25°C and a relative humidity below 60%. Ensure proper labeling and keep the compound out of reach of children and unauthorized personnel.