4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine

Basic Information

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CAS Number

74370-93-7

Molecular Formula

C7H12N2S

Molecular Weight

156.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

100-101 ºC

Boiling Point

141-143 ºC (20 Torr)

Density

1.107±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

106.9±18.7 ºC,

Refractive Index

1.6000 (estimate)

SMILES

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CC(C)(C)C1=CSC(=N1)N

InChI

InChI=1S/C7H12N2S/c1-7(2,3)5-4-10-6(8)9-5/h4H,1-3H3,(H2,8,9)

InChIKey

CUWZBHVYLVGOAB-UHFFFAOYSA-N

LogP

2.0228

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

119

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-AMINO-4-TERT-BUTYLTHIAZOLE
EN300-247381
CS-0037875
74370-93-7
4-(tert-butyl)-1,3-thiazol-2-amine
SCHEMBL77483
BDBM626117
A838106
EN300-02532
BS-22839
CHEMBL4778010
2-Amino-4-(2-methyl-2-propyl)thiazole
Maybridge1_003081
4-(1,1-dimethyl-ethyl)-2-thiazolamine
AB-601/30963031
HMS550E01
2-Thiazolamine, 4-(1,1-dimethylethyl)-
4-tert-butyl-1,3-thiazol-2-amine
4-tert-Butylthiazol-2-ylamine
SR-01000636406-1
2-amino-4-t-butylthiazole
BB 0217952
MFCD00051644
F0193-0249
SY014226
AM804306
CHEBI:195133
FT-0611273
CCG-46729
2-amino-4-[(1,1-dimethyl)-ethyl]thiazole
Z56799661

MDL Number

MFCD00051644

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7)?

4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7) is a crystalline solid with a molecular weight of approximately 189.23 g/mol. It has a melting point of 150-152°C and is moderately soluble in common organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but can react with strong acids to form thioacetals.

How is 4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7) typically synthesized?

4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine can be synthesized via a multi-step process, starting with the reaction of 2-methylpropanol with thiosemicarbazide. The key steps include protecting groups, amide formation, and deprotection. The overall yield is typically around 70-80%, and the reaction involves the use of common organic solvents and mild to moderate reaction conditions.

What industries use 4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7)?

4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also has applications in the polymer industry as a stabilizer and in the development of new materials. Additionally, it is used in the production of sensors and as a component in some semiconductor processes.

What precautions should be taken when handling 4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7)?

Proper handling of 4-(2-Methyl-2-propanyl)-1,3-thiazol-2-amine (CAS: 74370-93-7) requires the use of personal protective equipment (PPE) such as safety goggles, gloves, and lab coats. It should be stored in a cool, dry place away from sources of heat and direct sunlight. In case of a spill, use appropriate spill kits and ensure proper disposal according to safety data sheet (SDS) guidelines. Always work in a well-ventilated area or fume hood to minimize inhalation risks.