(5-Bromo-2-chloro-3-pyridinyl)methanol

Basic Information

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CAS Number

742100-75-0

Molecular Formula

C6H5BrClNO

Molecular Weight

222.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

76-78

Boiling Point

320.5°C at 760 mmHg

Density

1.785

Flash Point

147.6°C

Refractive Index

1.613

SMILES

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C1=C(C=NC(=C1CO)Cl)Br

InChI

InChI=1S/C6H5BrClNO/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2

InChIKey

ZZGSPGXWLOYKFH-UHFFFAOYSA-N

LogP

1.9898

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

114

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SCHEMBL1543624
AKOS005072650
CS-0053166
ZZGSPGXWLOYKFH-UHFFFAOYSA-N
FA-0723
(5-Bromo-2-chloro-pyridin-3-yl)-methanol
EN300-220501
(5-bromo-2-chloropyridin-3-yl)methanol
(5-bromanyl-2-chloranyl-pyridin-3-yl)methanol
(5-Bromo-2-chloro-pyridin-3-yl)-methanol, AldrichCPR
(5-BROMO-2-CHLORO-3-PYRIDYL)METHANOL
5-BROMO-2-CHLOROPYRIDINE-3-METHANOL
(5-bromo-2-chloro-3-pyridinyl)methanol
MFCD08688594
FT-0678309
J-501545
P10623
5-Bromo-2-chloro-3-pyridinemethanol
5-Bromo-2-chloro-3-(hydroxymethyl)pyridine
742100-75-0
PB17569
DTXSID60630509
A838064
3-Pyridinemethanol,5-bromo-2-chloro-
(5-Bromo-2-chloro-3-pyridinyl)methanol
(5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL
bromochloropyridinylmethanol

MDL Number

MFCD08688594

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (5-Bromo-2-chloro-3-pyridinyl)methanol (CAS: 742100-75-0)?

(5-Bromo-2-chloro-3-pyridinyl)methanol is a crystalline solid with a molecular weight of approximately 209.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. Chemically, it exhibits reactivity typical of methanol derivatives, including nucleophilic substitution and electrophilic aromatic substitution reactions.

How is (5-Bromo-2-chloro-3-pyridinyl)methanol (CAS: 742100-75-0) typically synthesized?

(5-Bromo-2-chloro-3-pyridinyl)methanol can be synthesized using a multi-step process involving bromination of 3-chloropyridine followed by methylation. The reaction involves the use of bromine and methyl halides as reagents, with catalysis by Lewis acids like aluminum trichloride. The yield and selectivity can be optimized through careful control of reaction conditions.

What industries use (5-Bromo-2-chloro-3-pyridinyl)methanol (CAS: 742100-75-0)?

(5-Bromo-2-chloro-3-pyridinyl)methanol is used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the polymer industry due to its potential to act as a monomer or functional group modifier. Additionally, it finds applications in the development of sensors and semiconductors for its aromatic and functional group properties.

What precautions should be taken when handling (5-Bromo-2-chloro-3-pyridinyl)methanol (CAS: 742100-75-0)?

When handling (5-Bromo-2-chloro-3-pyridinyl)methanol, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should be worn. Handling should be performed in a fume hood to minimize exposure to bromine and chlorine fumes. Spills should be cleaned up with the appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed emergency response procedures and storage recommendations.