6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Basic Information

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CAS Number

742-20-1

Molecular Formula

C13H18ClN3O4S2

Molecular Weight

379.89 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

230°

Boiling Point

605.6 °C at 760 mmHg

Density

1.3650 (rough estimate)

Flash Point

320.1 °C

Refractive Index

1.6100 (estimate)

SMILES

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C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl

InChI

InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

InChIKey

BKYKPTRYDKTTJY-UHFFFAOYSA-N

LogP

1.5976000000000001

Topological Polar Surface Area

118.35999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

637

Safety Information

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Toxicity

LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)

Synonyms & References

English

Su-8341
(-)-Cyclopenthiazide
Salimed
BRD-A41250306-001-03-4
CYCLOPENTHIAZIDE [USAN]
Navidrex
NSC-107679
CHEBI:91686
DTXSID4022868
DTXCID802868
SMR000528497
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
6-chloro-3-(cyclopentylmethyl)-1,1-diketo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
SR-01000776288
(+)-Cyclopenthiazide
Ciba 8341-Su
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
Benesal
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide, (+)-
BPBio1_001197
Cyclopentiazid
Ciclopentiazida
NCGC00179312-03
NSC107679
GTPL7899
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
CHEMBL1373254
Tox21_110481
VX4S2N85F5
Ultra-Minzil
96783-05-0

MDL Number

MFCD00865825

FAQ

What is 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (CAS: 742-20-1)?

6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, also known as Benzbromarone, is a sulfur-containing heterocyclic compound with a molecular formula of C16H18ClN4O3S. It is a white or off-white powder with a faint odor and is soluble in water and ethanol. This compound is known for its anti-inflammatory and uricosuric properties.

What are the main uses of 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (CAS: 742-20-1)?

6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, or Benzbromarone, is primarily used as an antihyperuricemic agent. It is effective in reducing serum uric acid levels and treating gout by promoting the excretion of uric acid through the kidneys.

Is 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (CAS: 742-20-1) safe?

While 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, or Benzbromarone, is generally safe when used as directed, it should be used with caution due to potential side effects such as liver toxicity and kidney impairment. It is important to follow the prescribed dosage and monitor for any adverse reactions.

How should 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (CAS: 742-20-1) be stored?

6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, or Benzbromarone, should be stored in a tightly closed container, protected from light and moisture. It should be kept at room temperature (15°C to 30°C/59°F to 86°F) and out of reach of children and pets. Avoid exposure to high temperatures and direct sunlight to maintain its stability.