(2E)-3-(4-Hydroxyphenyl)acrylic acid

Basic Information

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CAS Number

7400-08-0

Molecular Formula

C9H8O3

Molecular Weight

164.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

212-214 ºC

Boiling Point

346°C at 760 mmHg

Density

1.2132 (rough estimate)

Flash Point

177.3℃

Solubility

1.83e+004 mg/L @ 25 °C (est)

Refractive Index

1.5380 (estimate)

SMILES

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C1=C(C=CC(=C1)O)C=CC(O)=O

InChI

InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+

InChIKey

NGSWKAQJJWESNS-ZZXKWVIFSA-N

LogP

1.4899999999999998

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

178

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

3-(4-Hydroxyphenyl)acrylic acid
COUMARIC ACID, TRANS-P-
AKOS 221-47
AKOS BAR-2479
(2E)-3-(4-Hydroxyphenyl)-2-propenoic acid
3-(4-Hydroxyphenyl)-2-propenoic acid
3-(4-hydroxyphenyl)-2-propenoicaci
p-Hydroxy-cinnamic acid
4-Coumaric acid
4-Hydroxycinnamic Acid,mixture of cis and trans
COUMARIC ACID, 4-(4-HYDROXYCINNAMIC ACID)(RG)
p-Coumaric acid
P-hydroxycinnamic acid
4-Hydroxycinnamic Acid
对羟基肉桂酸
trans-4-Hydroxycinnamic acid
trans-p-Coumaric acid
p-Cumaric acid
Para-Coumaric acid
Hydroxycinnamic acid
Naringeninic acid
p-Hydroxyphenylacrylic acid
(E)-p-Coumaric acid
trans-p-Coumarinic acid
4'-hydroxycinnamic acid
(E)-3-(4-Hydroxyphenyl)acrylic acid
Cinnamic acid, p-hydroxy-
(E)-p-Hydroxycinnamic acid
trans-p-Hydroxycinnamic acid
2-propenoic acid, 3-(4-hydroxyphe
p-Coumaric acid,3-(4-Hydroxyphenyl)acrylic acid,NSC 59260,NSC 674321,β-[4-Hydroxyphenyl]acrylic acid...

MDL Number

MFCD00004399

FAQ

What is (2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0)?

(2E)-3-(4-Hydroxyphenyl)acrylic acid, with CAS number 7400-08-0, is a conjugated enone compound containing a hydroxyl group on the benzene ring. Its chemical formula is C10H10O3, and it exhibits acidic properties due to the carboxylic acid group. This compound is known for its reactivity in organic synthesis and is commonly used as an intermediate in pharmaceutical and industrial applications.

What are the main uses of (2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0)?

(2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0) is widely utilized in pharmaceuticals for drug development, including antihistamines and anti-inflammatory agents. It also serves as a key component in industrial processes for creating polymers, coatings, and UV absorbers. In research, it functions as a building block for synthesizing other organic compounds and is relevant in studies involving chemical reactivity and functional group modifications.

Is (2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0) safe?

The safety of (2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0) depends on handling conditions. It is generally considered low toxicity but may cause skin or eye irritation. Precautions include wearing gloves, safety goggles, and ensuring proper ventilation. Compliance with OSHA and EPA guidelines is recommended, and it should be stored away from incompatible materials to prevent accidental exposure or environmental harm.

How should (2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0) be stored?

(2E)-3-(4-Hydroxyphenyl)acrylic acid (CAS: 7400-08-0) should be stored in a cool, dry, and dark place, ideally at 25°C (77°F) with low humidity. It requires a tightly sealed container to avoid moisture ingress and degradation. Protection from light is essential to maintain stability, and it should be kept in a well-ventilated area to prevent vapor accumulation. Always store away from heat sources and incompatible chemicals.