Indomethacin (Indometacin) EP Impurity A (Indomethacin USP Related Compound B, Acemetacin EP Impurity A, Bezafibrate EP Impurity B, Clopamide EP Impurity B)

Basic Information

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CAS Number

74-11-3

Molecular Formula

C7H5ClO2

Molecular Weight

156.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

238-241 °C

Boiling Point

274-276 ºC (subl.)

Density

1.54

Solubility

methanol: soluble1%, clear, colorless to faintly yellow

Refractive Index

1.5812 (estimate)

Vapor Pressure

0.0±0.6 mmHg at 25°C

SMILES

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C1=CC(=CC=C1C(=O)O)Cl

InChI

InChI=1S/C7H5ClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)

InChIKey

XRHGYUZYPHTUJZ-UHFFFAOYSA-N

LogP

2.0382

pKa

3.98(at 25℃)

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

128

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Combustible. Incompatible with bases, strong oxidizing agents.

Sensitiveness

Sensitive to humidity

Synonyms & References

English

PS-4074
INDOMETACIN IMPURITY A [EP IMPURITY]
74-11-3
NCGC00090858-02
P-CHLOROBENZOIC ACID
DB03728
BDBM50405318
NCGC00090858-01
CHLOROBENZOIC ACID, P-
AKOS000118962
Z104473324
Q2235989
DTXSID9024772
STL164311
4-Chlorobenzoic acid, analytical standard
FT-0618183
Acido p-clorobenzoico
CCRIS 5994
Tox21_400062
IC7888DF4L
NCIOpen2_004782
SCHEMBL28384
CS-M3680
MLS002152923
NSC8444
S3 (4-chlorobenzoic acid)
4-09-00-00973 (Beilstein Handbook Reference)
P-CHLOROBENZOIC ACID [WHO-DD]
SMR001224523
CHEBI:30747
Acemetacin impurity A, European Pharmacopoeia (EP) Reference Standard

MDL Number

MFCD00002531

Customs Code

4002191900

FAQ

What is Indomethacin (CAS: 74-11-3)?

Indomethacin (CAS 74-11-3) is a nonsteroidal anti-inflammatory drug (NSAID) used primarily for its analgesic, antipyretic, and anti-inflammatory properties. Its chemical formula is C19H26O5, and it is a white to off-white crystalline powder with high solubility in organic solvents. It is commonly used in pharmaceutical formulations for pain and inflammation management.

What are the main uses of Indomethacin (CAS: 74-11-3)?

Indomethacin (CAS 74-11-3) is primarily used as an NSAID for treating pain, fever, and inflammation. It is also employed as a related compound in drug quality control, such as EP Impurity A and USP Related Compound B. In research settings, it serves as a reference standard for analyzing impurities in pharmaceutical products.

Is Indomethacin (CAS: 74-11-3) safe?

Indomethacin (CAS 74-11-3) is generally safe when used as directed, but it may cause side effects such as gastrointestinal issues, renal impairment, and cardiovascular risks. Proper handling and storage are essential to ensure safety. It is important to follow safety guidelines and regulatory standards when working with this compound in a laboratory or industrial setting.

How should Indomethacin (CAS: 74-11-3) be stored?

Indomethacin (CAS 74-11-3) should be stored in a cool, dry place away from light. It is typically kept in airtight containers to maintain stability and prevent moisture absorption. Storage conditions should be controlled at 2-8°C (36-46°F) and humidity levels below 60% to preserve its chemical integrity and ensure long-term usability.