N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine

Basic Information

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CAS Number

73724-45-5

Molecular Formula

C18H17NO5

Molecular Weight

327.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

97-107°C

Boiling Point

599.3±50.0 °C at 760 mmHg

Density

1.3620

Flash Point

316.2±30.1 °C

Refractive Index

-12.5 ° (C=1, DMF)

Specific Rotation

-12.5 º (c=1%, DMF)

SMILES

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C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CO)C(=O)O

InChI

InChI=1S/C18H17NO5/c20-9-16(17(21)22)19-18(23)24-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16,20H,9-10H2,(H,19,23)(H,21,22)/t16-/m0/s1

InChIKey

JZTKZVJMSCONAK-INIZCTEOSA-N

LogP

1.9706

Topological Polar Surface Area

95.86 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

446

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD00051928
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-SERINE
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-serine
Fmoc-Ser-OH
AKOS010368217
Fmoc-Ser-OH H2O
(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-HYDROXYPROPANOIC ACID
Q-101655
J-300238
FMOC-SER
AC-26241
73724-45-5
N-Fmoc-L-Ala(OH)
JZTKZVJMSCONAK-INIZCTEOSA-N
AS-12712
M03381
fmoc-serine
Fmoc-Ser-OH H
N-Fmoc-L-serine
AM20041095
Fmoc-Ser-OH, >=97.0% (sum of enantiomers, HPLC)
Fmoc-L-Ser-OH
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropanoic acid
(S)-FMOC-2-AMINO-3-HYDROXYPROPIONIC ACID
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic acid
F0454
AKOS015924249
EN300-81251
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine
HY-W007720
SCHEMBL118370

MDL Number

MFCD00051928

Customs Code

2924299090

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) is a protected amino acid derivative commonly used in organic synthesis. It contains a serine moiety linked to a fluorenylmethoxy carbonyl (Fmoc) group, which is widely employed as a temporary protecting group in peptide chemistry. Its molecular formula is C21H24N2O5, and it is typically a white crystalline solid with moderate solubility in organic solvents.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) is primarily used in pharmaceutical research and peptide synthesis. It serves as a building block for the preparation of various biologically active compounds, including drug candidates and bioconjugates. Its role in protecting the amino group during chemical reactions makes it valuable in the development of complex molecules in medicinal chemistry.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) is generally considered safe when handled properly. However, as with many chemical compounds, it should be treated with caution. Protective equipment such as gloves and goggles is recommended during handling. Safety data sheets (SDS) should be consulted for specific guidelines on exposure limits and emergency procedures.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine (CAS: 73724-45-5) should be stored in a cool, dry place away from light. It is best kept in a sealed container at a temperature below 25°C to maintain stability. Proper storage conditions help prevent degradation and ensure the compound remains suitable for use in laboratory and industrial applications.