1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Basic Information

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CAS Number

73627-18-6

Molecular Formula

C8H12N2

Molecular Weight

136.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1C2=CC=CN2CCN1

InChI

InChI=1S/C8H12N2/c1-7-8-3-2-5-10(8)6-4-9-7/h2-3,5,7,9H,4,6H2,1H3

InChIKey

JPXCPEMQVOKKFV-UHFFFAOYSA-N

LogP

1.1523

Topological Polar Surface Area

16.96 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

124

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Synonyms & References

English

1,2,3,4-TETRAHYDRO-1-METHYLPYRROLO(1,2-a)PYRAZINE
EN300-06743
AKOS016050259
SY101595
AM20100709
1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine
DTXSID20391326
1-methyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine
AKOS000575137
SCHEMBL929068
BB 0221003
1-Methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine
1,2-DI[PERDEUTERO]HEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1-Methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine;1-METHYL-1,2,3,4-TETRAHYDROPYRROLO[1,2-A]PYRAZINE
1-Methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine, AldrichCPR
MFCD00296984
CS-0106296
FT-0648699
73627-18-6
Z56943354
A866057
DS-0305
1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
AB05925
Pyrrolo[1,2-a]pyrazine,1,2,3,4-tetrahydro-1-methyl-
1-methyl-1,2,3,4-tetra-hydropyrrolo[1,2-a]pyrazine
1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine(SALTDATA: HCl 0.1H2O)
1-methylpyrrolo[1,2-a]piperazine
JPXCPEMQVOKKFV-UHFFFAOYSA-N
STK693515
SBB014867

MDL Number

MFCD00296984

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (CAS: 73627-18-6)?

1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine is a solid with a crystalline form. Its molecular weight is approximately 184.22 g/mol. This compound is slightly soluble in water but has good solubility in organic solvents like ethanol and dimethylformamide. It shows moderate reactivity towards common nucleophiles and electrophiles, with a pKa of around 8.5.

How is 1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (CAS: 73627-18-6) typically synthesized?

1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine can be synthesized via a multistep process involving the condensation of 1-methyl-3,4-dihydropyrrole with hydrazine hydrate. Commonly, this reaction is catalyzed by acetic acid, and it provides good selectivity and a yield of up to 85%. Further derivatization can be achieved via standard organic transformations.

What industries use 1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (CAS: 73627-18-6)?

1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine is used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer industry, where it can be incorporated into polymer matrices to improve their mechanical properties. Additionally, this compound is utilized in the development of sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (CAS: 73627-18-6)?

When handling 1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up promptly with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.