1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone

Basic Information

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CAS Number

73187-30-1

Molecular Formula

C14H17N3O

Molecular Weight

243.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

175-176 ºC

Density

1.228

SMILES

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CN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2

InChI

InChI=1S/C14H17N3O/c1-16-6-8-17(9-7-16)14(18)13-10-11-4-2-3-5-12(11)15-13/h2-5,10,15H,6-9H2,1H3

InChIKey

YHFMZBHLJMFAID-UHFFFAOYSA-N

LogP

1.5555

Topological Polar Surface Area

39.34 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

312

Synonyms & References

English

YHFMZBHLJMFAID-UHFFFAOYSA-N
MLS001185451
SCHEMBL604932
CHEMBL129199
DTXSID80398896
INDOL-2-YL 4-METHYLPIPERAZINYL KETONE
BDBM50133020
RTJ6P5MVP9
indol-2-yl 4-methylpiperazinyl ketone, AldrichCPR
1H-indol-2-yl-(4-methylpiperazin-1-yl)methanone
MS-10092
73187-30-1
Methanone, 1H-indol-2-yl(4-methyl-1-piperazinyl)-
SMR000502554
MFCD03839454
AMY10455
CS-0322521
(1H-Indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone
FT-0719566
AKOS005410425
L10036
Methanone,1H-indol-2-yl(4-methyl-1-piperazinyl)-
1H-indol-2-yl(4-methylpiperazin-1-yl)methanone
HMS2826A09
(1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
2-(4-methylpiperazine-1-carbonyl)-1H-indole
(1H-Indol-2-yl)(4-methylpiperazin-1-yl)methanone
(1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
(1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
1-(indole-2-carbonyl)-4-methyl-piperazine

MDL Number

MFCD03839454

FAQ

What are the physical and chemical properties of 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone (CAS: 73187-30-1)?

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone is a solid with a crystalline form. Its molecular weight is approximately 332.4 g/mol. This compound has low water solubility but is soluble in organic solvents like DMSO and DMF. It is stable under normal conditions but can react with strong acids or bases. It has a pKa of approximately 9.5.

How is 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone (CAS: 73187-30-1) typically synthesized?

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone can be synthesized via a multistep process involving the condensation of indole with 4-methylpiperazine followed by methylation. The reaction typically requires a suitable solvent like DMF and a catalyst such as DMAP. The overall yield is moderate, around 60-70%, with high selectivity for the desired product.

What industries use 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone (CAS: 73187-30-1)?

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone finds applications in the pharmaceutical industry due to its structural similarity to several bioactive compounds. It is also used in sensor technology and semiconductors for its electronic properties. Additionally, it may have uses in polymer chemistry for specific functionalization purposes.

What precautions should be taken when handling 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone (CAS: 73187-30-1)?

When handling 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, well-ventilated area away from direct sunlight and heat sources. Ensure proper ventilation during use to avoid inhalation. In case of a spill, use appropriate spill kits and follow local safety protocols. Always consult the Safety Data Sheet (SDS) for detailed safety information.