1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone(CAS: 73187-30-1)

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone is a solid with a crystalline form. Its molecular weight is approximately 332.4 g/mol. This compound has low water solubility but is soluble in organic solvents like DMSO and DMF. It is stable under normal conditions but can react with strong acids or bases. It has a pKa of approximately 9.5.

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone can be synthesized via a multistep process involving the condensation of indole with 4-methylpiperazine followed by methylation. The reaction typically requires a suitable solvent like DMF and a catalyst such as DMAP. The overall yield is moderate, around 60-70%, with high selectivity for the desired product.

1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone finds applications in the pharmaceutical industry due to its structural similarity to several bioactive compounds. It is also used in sensor technology and semiconductors for its electronic properties. Additionally, it may have uses in polymer chemistry for specific functionalization purposes.

When handling 1H-Indol-2-yl(4-methyl-1-piperazinyl)methanone, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, well-ventilated area away from direct sunlight and heat sources. Ensure proper ventilation during use to avoid inhalation. In case of a spill, use appropriate spill kits and follow local safety protocols. Always consult the Safety Data Sheet (SDS) for detailed safety information.