5-(4-Chlorophenyl)-1,3-thiazol-2-amine

Basic Information

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CAS Number

73040-66-1

Molecular Formula

C9H7ClN2S

Molecular Weight

210.69 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

203-204 ºC

Boiling Point

389.8°C at 760 mmHg

Density

1.389

SMILES

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C1=CC(=CC=C1C2=CN=C(S2)N)Cl

InChI

InChI=1S/C9H7ClN2S/c10-7-3-1-6(2-4-7)8-5-12-9(11)13-8/h1-5H,(H2,11,12)

InChIKey

AABPJRCTFLZVAL-UHFFFAOYSA-N

LogP

3.045700000000001

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

171

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

FS-3705
Z732776068
EN300-215218
FT-0689692
DTXSID70501276
5-(4-CHLOROPHENYL)-2-THIAZOLAMINE
5-(4-chlorophenyl)-1,3-thiazol-2-amine
A837702
AKOS010254505
73040-66-1
2-Amino-5-(4-chlorophenyl)thiazole
MFCD12779839
CS-W022247
5-(4-Chlorophenyl)thiazol-2-amine
5-(4-Chlorophenyl)-1,3-thiazol-2-amine
5-(4-chlorophenyl)-2-Thiazolamine
5-(4-chlorophenyl)-2-amino-1,3-thiazole
AB0056983
Z5075
ST24023754
779C839
Z1741981044

MDL Number

MFCD12779839

FAQ

What are the physical and chemical properties of 5-(4-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 73040-66-1)?

5-(4-Chlorophenyl)-1,3-thiazol-2-amine is a crystalline solid with a molecular weight of approximately 258.9 g/mol. It has a solubility of 5.6 g/L in water and is slightly soluble in common organic solvents such as ethanol. The compound is reactive towards acid and base catalysts, making it suitable for various organic transformations. It is important to handle it under mild conditions to avoid decomposition.

How is 5-(4-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 73040-66-1) typically synthesized?

5-(4-Chlorophenyl)-1,3-thiazol-2-amine is commonly synthesized via the condensation of 4-chlorophenyl isothiocyanate with thiosemicarbazide. This reaction is typically carried out in an aqueous medium with moderate temperatures and yields around 85%. The use of suitable catalysts and efficient workup procedures enhances the selectivity and overall yield of the desired product.

What industries use 5-(4-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 73040-66-1)?

5-(4-Chlorophenyl)-1,3-thiazol-2-amine finds applications in the pharmaceutical industry as an intermediate for synthesizing active pharmaceutical ingredients. It is also used in the production of sensors and semiconductor materials due to its unique chemical properties.

What precautions should be taken when handling 5-(4-Chlorophenyl)-1,3-thiazol-2-amine (CAS: 73040-66-1)?

When handling 5-(4-Chlorophenyl)-1,3-thiazol-2-amine, it is crucial to wear personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. Proper storage in a cool, dry place away from heat and moisture is essential. In case of a spill, immediately clean up using appropriate absorbents and follow the safety data sheet (SDS) guidelines for disposal.