Phentolamine hydrochloride

Basic Information

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CAS Number

73-05-2

Molecular Formula

C17H20ClN3O

Molecular Weight

317.82 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

>230 (dec.)°C

Boiling Point

308.1±52.0 °C at 760 mmHg

Density

1.3±0.1 g/cm3

Flash Point

140.2±30.7 °C

Solubility

methanol: 10 mg/mL, clear, colorless

Vapor Pressure

0.0±0.7 mmHg at 25°C

SMILES

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CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.Cl

InChI

InChI=1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

InChIKey

TUEJFGFQYKDAPM-UHFFFAOYSA-N

LogP

3.2622200000000015

Topological Polar Surface Area

47.86 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

363

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1(b) Class 6.1(b)

Toxicity

LD50 in rats (mg/kg): 75 i.v.; 275 s.c.; 1250 orally (Meier)

Synonyms & References

English

Phentolamine hydrochloride, United States Pharmacopeia (USP) Reference Standard
PHENOL, 3-(((4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL)(4-METHYLPHENYL)AMINO)-, HYDROCHLORIDE (1:1)
Phentolamine hydrochloride [USP]
NCGC00094835-03
Regitine hydrochloride
Phentolaminehydrochloride
UNII-86DRW83R1H
3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol
NSC-757431
AS-16924
SR-01000000055-11
3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol Hydrochloride
3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;hydrochloride
CHEMBL1204146
PHENTOLAMINE HYDROCHLORIDE [MI]
DTXSID40223271
Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino), monohydrochloride
PHENTOLAMINE HYDROCHLORIDE [WHO-DD]
FT-0673687
HY-12717A
3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol (HCl)
HMS1921E06
SR-01000000055
C17H19N3O.ClH
EINECS 200-793-5
Pharmakon1600-01500691
MFCD00079268
NCGC00094835-04
3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;hydron;chloride
NSC757431
m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monohydrochloride

MDL Number

MFCD09998939

FAQ

What is Phentolamine hydrochloride (CAS: 73-05-2)?

Phentolamine hydrochloride (CAS: 73-05-2) is an α-adrenergic receptor antagonist used as a vasodilator. It is a white crystalline powder with a molecular formula of C10H14N2O.HCl, and a molecular weight of 205.7 g/mol.

What are the main uses of Phentolamine hydrochloride (CAS: 73-05-2)?

Phentolamine hydrochloride (CAS: 73-05-2) is primarily used as a vasodilator to treat hypertension and certain cardiovascular conditions. It is also used in the management of pheochromocytoma and in diagnostic tests to differentiate between sympathetic and parasympathetic causes of vasodilation.

Is Phentolamine hydrochloride (CAS: 73-05-2) safe?

Phentolamine hydrochloride (CAS: 73-05-2) is generally considered safe when used as directed under medical supervision. However, it can cause side effects such as hypotension and tachycardia. Users should follow medical advice and take necessary precautions, such as avoiding driving or operating heavy machinery.

How should Phentolamine hydrochloride (CAS: 73-05-2) be stored?

Phentolamine hydrochloride (CAS: 73-05-2) should be stored in a tightly closed container, protected from light and heat. Store at room temperature (15°C to 30°C) and avoid excessive humidity. Keep out of reach of children and pets.