1,6-Naphthyridin-4-ol

Basic Information

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CAS Number

72754-01-9

Molecular Formula

C8H6N2O

Molecular Weight

146.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=CNC2=C(C1=O)C=NC=C2

InChI

InChI=1S/C8H6N2O/c11-8-2-4-10-7-1-3-9-5-6(7)8/h1-5H,(H,10,11)

InChIKey

WFLDCLHOLPDVCP-UHFFFAOYSA-N

LogP

0.9230999999999998

Topological Polar Surface Area

45.75 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

200

Synonyms & References

English

1,6-NAPHTHYRIDIN-4-OL
1,4-Dihydro-1,6-naphthyridine-4-one
FT-0690919
AKOS006277476
1.6-naphthyridin-4-ol
J-504040
1,6-Naphthyridin-4(1H)-one
72754-01-9
CS-0060296
MFCD02684596
AKOS016054230
A858226
1-H-[1,6]Naphthyridin-4-one
1,4-dihydro-1,6-naphthyridin-4-one
[1,6]NAPHTHYRIDIN-4-OL
LF-0708
1H-1,6-naphthyridin-4-one
F13211
1,4-dihydro-4-oxo-1,6-naphthyridine
SCHEMBL277031
ZB0082
4-hydroxy-1,6-naphthyridine
EN300-85394
1h-[1,6]naphthyridin-4-one
5268-38-2
WFLDCLHOLPDVCP-UHFFFAOYSA-N
Z1335657679
FT-0740689
XCA75401
1,4-Dihydro-1,6-naphthyridin-4-one
1,6-Naphthyridin-4-ol

MDL Number

MFCD02684596

FAQ

What are the physical and chemical properties of 1,6-Naphthyridin-4-ol (CAS: 72754-01-9)?

1,6-Naphthyridin-4-ol (CAS: 72754-01-9) is a white to off-white crystalline solid with a molecular weight of approximately 155.15 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong acids and bases. It forms colorless solutions in water and exhibits mild reactivity, especially under basic conditions.

How is 1,6-Naphthyridin-4-ol (CAS: 72754-01-9) typically synthesized?

1,6-Naphthyridin-4-ol (CAS: 72754-01-9) can be synthesized via a condensation reaction between 6-nitronaphthalen-1-one and hydrazine hydrate, followed by reduction and hydrolysis. This method provides good yields and selectivity. Other routes involve the use of naphthalene and hydrazine derivatives, often requiring specific catalysts and conditions to ensure high purity and efficiency.

What industries use 1,6-Naphthyridin-4-ol (CAS: 72754-01-9)?

1,6-Naphthyridin-4-ol (CAS: 72754-01-9) is primarily used in the pharmaceutical industry for the synthesis of certain medicinal compounds, particularly as a precursor in drug development. It also finds applications in polymer science for the preparation of functional polymers, and in sensor technology due to its unique optical properties. Additionally, it is utilized in the semiconductor industry for specific chemical processes.

What precautions should be taken when handling 1,6-Naphthyridin-4-ol (CAS: 72754-01-9)?

When handling 1,6-Naphthyridin-4-ol (CAS: 72754-01-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using appropriate absorbents, and proper disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.