Ceftazidime | CAS No. 72558-82-8

Ceftazidime

Basic Information

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CAS Number

72558-82-8

Molecular Formula

C22H22N6O7S2

Molecular Weight

546.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

No data available

Boiling Point

No data available

Flash Point

No data available

Vapor Pressure

No data available

SMILES

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CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]

InChI

InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1

InChIKey

ORFOPKXBNMVMKC-DWVKKRMSSA-N

LogP

-1.60

Complexity

1020

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Stability

Stable, but keep refrigerated. Incompatible with strong oxidizing agents, nitric acid, permanganates, peroxides.

Synonyms & References

English

78439-06-2
Ceptaz (TN)
DB00438
7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-(pyridinium-1-ylmethyl)-3,4-didehydrocepham-4-carboxylate
LY-139381
Tazicef
Fortaz (TN)
EN300-22411480
AB00513848
CHEBI:3508
CHEMBL44354
(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
AKOS015951273
E-Ceftazidime
HY-B0593
CEFTAZIDIME (ARGININE FORMULATION)
(6R,7R)-7-[[2-(2-Amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
BDBM50420259
Ceftazidime (TN)
Fortaz
NSC-759260
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Q-200811
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Ceptaz
GR 20263
(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (contains ca. 10% Na2CO3)
Ceftazidime anhydrous
Tazidime
ceftazidime
CCG-269983

MDL Number

MFCD00072034

Customs Code

2941905990

FAQ

What is Ceftazidime (CAS: 72558-82-8)?

Ceftazidime is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. Its chemical formula is C16H17N5O4S2, and it exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria. It is known for its stability in the presence of beta-lactamases and is commonly used in clinical settings for severe infections.

What are the main uses of Ceftazidime (CAS: 72558-82-8)?

Ceftazidime is primarily used in medicine to combat bacterial infections, including respiratory, urinary, and skin infections. It is also effective against intra-abdominal infections and sepsis. Due to its broad-spectrum activity, it is a key component in antibiotic therapy for patients with compromised immune systems or severe infections. Its use is supported by its efficacy against Pseudomonas aeruginosa and other resistant pathogens.

Is Ceftazidime (CAS: 72558-82-8) safe?

Ceftazidime is generally considered safe when used as directed, but it may cause side effects such as gastrointestinal discomfort, allergic reactions, or nephrotoxicity in some cases. It should be handled with care, following standard safety protocols for antibiotics. Safety standards include proper personal protective equipment (PPE) during preparation and administration to minimize exposure risks.

How should Ceftazidime (CAS: 72558-82-8) be stored?

Ceftazidime should be stored in a cool, dry place, away from moisture and light. It is typically kept at a temperature between 2°C to 8°C (refrigerated) and should be protected from freezing. The compound should be stored in airtight containers to maintain stability and prevent degradation. Proper storage ensures its efficacy and safety for use.