N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine

Basic Information

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CAS Number

71989-35-0

Molecular Formula

C23H27NO5

Molecular Weight

397.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

131.0 to 135.0 deg-C

Boiling Point

520.91°C (rough estimate)

Density

1.2197 (rough estimate)

Flash Point

305.6℃

Refractive Index

15 ° (C=1, AcOEt)

Specific Rotation

40 º (c=1, chloroform)

SMILES

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CC(C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OC(C)(C)C

InChI

InChI=1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/t14-,20+/m1/s1

InChIKey

LZOLWEQBVPVDPR-VLIAUNLRSA-N

LogP

4.181900000000002

Topological Polar Surface Area

84.86 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

564

Safety Information

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GHS Hazard Pictograms

H410

Hazard Statement

H410 Very toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Synonyms & References

English

Fmoc-Thr(t-Bu)-OH
AM82252
O-tert-Butyl-Nalpha-Fmoc-L-threonine
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-threonine
AKOS015840843
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine
LZOLWEQBVPVDPR-VLIAUNLRSA-N
(2S,3R)-3-(tert-butoxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid
F0505
SCHEMBL1738651
Fmoc-Thr(tBu)-OH, >=98.0% (HPLC)
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylthreonine
N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-threonine (Fmoc-L-Thr(OtBu)-OH)
Fmoc-O-tert-butyl-L-threonine
EN300-249917
Fmoc-O-tert.butyl-L-threonine
HY-W007706
Fmoc-Thr(tBu)-OH
(2S,3R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-tert-butoxybutanoic acid
M03389
(2S,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-threonine
MFCD00077075
Nalpha-Fmoc-O-tert-butyl-L-threonine
(2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]butanoic acid
(2S,3R)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
71989-35-0
CS-W007706
9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-THEONINE
AS-14178
(2S,3R)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid

MDL Number

MFCD00077075

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0) is a protected amino acid derivative commonly used in organic synthesis. It contains a threonine backbone with a fluorene methoxy carbonyl group and a tert-butyl protecting group, making it suitable for controlled peptide and protein synthesis. Its molecular formula is C21H32N2O5, and it is typically a white to off-white solid with good solubility in organic solvents.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0)?

This compound is widely used in pharmaceutical research for the synthesis of peptides and bioactive molecules. It also finds applications in organic chemistry as a building block for more complex structures. Additionally, it is employed in the development of drug candidates and in biochemical studies due to its stability and reactivity in controlled environments.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0) is generally considered safe when handled properly. It is not classified as harmful under standard safety protocols, but as with any chemical, appropriate protective measures such as gloves and ventilation should be taken. Always follow safety guidelines specific to laboratory handling and storage.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-threonine (CAS: 71989-35-0) should be stored in a cool, dry, and dark place, preferably at 2-8°C. It should be kept in a sealed container to prevent moisture exposure and maintain stability. Avoid prolonged exposure to light and air to preserve its chemical integrity.