1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline

Basic Information

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CAS Number

71989-31-6

Molecular Formula

C20H19NO4

Molecular Weight

337.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

117-118 °C

Boiling Point

548.6°C at 760 mmHg

Density

1.2486 (rough estimate)

Flash Point

285.6℃

Solubility

Soluble in methanol. (almost transparency.)

Refractive Index

-32.5 ° (C=1, DMF)

Specific Rotation

-32 º (c=1,DMF)

SMILES

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C1CC(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

InChI

InChI=1S/C20H19NO4/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,22,23)/t18-/m0/s1

InChIKey

ZPGDWQNBZYOZTI-SFHVURJKSA-N

LogP

3.4845000000000024

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

500

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Fmoc-Pro-OH, >=99.0% (HPLC)
FMOC-PRO
DTXSID401318313
N-FMOC-L-PROLINE
L-Proline-N-Fmoc
(S)-N-(9-Fluorenylmethoxycarbonyl)proline
M03372
SCHEMBL118354
MFCD00037122
Fmoc-Pro-OH.nH2O
(2S)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
(S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID
CS-W014496
CHEMBL4637507
(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
NS00064249
Fmoc-L-proline
AKOS012535968
CS-11264
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-proline
Fmoc-Pro-OH
71989-31-6
F0298
Fmoc-L-Pro-OH
EN300-81243
ZPGDWQNBZYOZTI-SFHVURJKSA-N
Z1123720062
(S)-FMOC-PYRROLIDINE-2-CARBOXYLIC ACID
N-(9-Fluorenylmethoxycarbonyl)-L-proline
J-300224
HY-W013780

MDL Number

MFCD00037122

FAQ

What is 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6)?

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) is a proline derivative featuring a fluorenylmethoxy carbonyl group. It is a white solid with a molecular formula of C19H22N2O3, commonly used in organic synthesis. The compound exhibits stability under standard conditions and is characterized by its chiral structure, making it valuable in pharmaceutical and research applications.

What are the main uses of 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6)?

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) is primarily used in pharmaceutical research as a chiral auxiliary and building block for drug synthesis. It also finds applications in organic chemistry for creating complex molecules, peptide chemistry, and as a protected amino acid. Its utility stems from the fluorenylmethoxy carbonyl (Fmoc) group, which is essential in solid-phase peptide synthesis and functional group manipulation.

Is 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) safe?

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) is generally considered safe when handled properly. However, it is advisable to use protective gloves, goggles, and lab coats to prevent skin or eye contact. While not classified as highly toxic, standard laboratory safety protocols should be followed, and it should be stored in a well-ventilated area to minimize exposure risks.

How should 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) be stored?

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline (CAS: 71989-31-6) should be stored in a cool, dry, and dark place, preferably at 2-8°C. It requires airtight containers to protect from moisture and light, ensuring stability. Avoid exposure to high humidity and direct sunlight to prevent degradation. Keep away from incompatible substances and follow proper labeling for safe handling.