SN-38-d | CAS No. 718612-49-8

SN-38-d

Basic Information

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CAS Number

718612-49-8

Molecular Formula

C22H17D3N2O5

Molecular Weight

395.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

227-233°C (dec.)

SMILES

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CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O

InChI

InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1/i1D3

InChIKey

FJHBVJOVLFPMQE-MVTYLIICSA-N

LogP

2.3476000000000004

Topological Polar Surface Area

101.64999999999999 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

820

Synonyms & References

English

SN-38-d3
(4S)-4-Ethyl-11-(2,2,2-~2~H_3_)ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(19S)-19-Ethyl-7,19-dihydroxy-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
CS-0202069
DTXSID90849647
718612-49-8
CID 71434326
AKOS030243294
HY-13704S
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-11-(ethyl-2,2,2-d3)-4,9-dihydroxy-, (4S)- (9CI)
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-11-(ethyl-2,2,2-d3)-...
(4S)-4-Ethyl-11-(ethyl-d3)-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-Hydroxy-7-ethylcamptothecin-d3
7-Ethyl-10-hydroxycamptothecin-d3
SN 38-d3 Lactone
SN-38-d

MDL Number

MFCD09841270

FAQ

What is SN-38-d (CAS: 718612-49-8)?

SN-38-d is a derivative of irinotecan, a topoisomerase I inhibitor used in chemotherapy. It has a molecular formula of C27H29N3O8S. SN-38-d exhibits potent antitumor activity and is used in preclinical studies to evaluate its anticancer potential.

What are the main uses of SN-38-d (CAS: 718612-49-8)?

SN-38-d is primarily used in preclinical research to study the pharmacological effects and mechanisms of action of irinotecan derivatives. It is also used in laboratory settings to assess the efficacy and safety profile of these compounds in cancer treatment.

Is SN-38-d (CAS: 718612-49-8) safe?

SN-38-d is generally safe under controlled laboratory conditions when handled with appropriate safety measures. However, it is cytotoxic and should be used with caution to avoid skin contact and inhalation. Protective equipment and proper disposal methods are essential.

How should SN-38-d (CAS: 718612-49-8) be stored?

SN-38-d should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container and protected from moisture. The compound should be handled in a fume hood and stored in a secure and accessible but controlled environment to prevent unauthorized access.