2-Chloro-5-(difluoromethyl)pyridine

Basic Information

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CAS Number

71701-99-0

Molecular Formula

C6H4ClF2N

Molecular Weight

163.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

215.1±35.0 ºC (760 Torr),

Density

1.368 g/mL at 25 °C

Refractive Index

n20/D 1.492

SMILES

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C1=CC(=NC=C1C(F)F)Cl

InChI

InChI=1S/C6H4ClF2N/c7-5-2-1-4(3-10-5)6(8)9/h1-3,6H

InChIKey

OSQYJPKSEWBNOE-UHFFFAOYSA-N

LogP

2.672600000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

110

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

FT-0686351
DTXSID40630082
SY305997
2-Chloro-5-(difluoromethyl)pyridine, 97%
6-Chloro-3-(difluoromethyl)pyridine
AKOS005258396
MS-20435
WCA70199
TQP0184
D80116
2-CHLORO-5-(DIFLUOROMETHYL)PYRIDINE
CS-0132554
F2147-6846
MFCD16140199
SCHEMBL2120568
AB70755
EN300-207006
71701-99-0
2-chloro-5-(difluoromethyl)-Pyridine
2-Chloro-5-(difluoromethyl)pyridine

MDL Number

MFCD16140199

FAQ

What are the physical and chemical properties of 2-Chloro-5-(difluoromethyl)pyridine (CAS: 71701-99-0)?

2-Chloro-5-(difluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 197.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is relatively stable but can react with strong bases or reducing agents under certain conditions.

How is 2-Chloro-5-(difluoromethyl)pyridine (CAS: 71701-99-0) typically synthesized?

2-Chloro-5-(difluoromethyl)pyridine can be synthesized via nucleophilic substitution of a chlorinated pyridine with difluoromethyl Grignard reagent. Commonly, this is achieved using a two-step process involving the first formation of a chloropyridine derivative followed by alkylation with a difluoromethyl Grignard reagent.

What industries use 2-Chloro-5-(difluoromethyl)pyridine (CAS: 71701-99-0)?

2-Chloro-5-(difluoromethyl)pyridine is primarily used in the pharmaceutical industry for the synthesis of various drugs, particularly in the development of antiviral compounds. It has also found applications in research and development for materials science and sensor technology.

What precautions should be taken when handling 2-Chloro-5-(difluoromethyl)pyridine (CAS: 71701-99-0)?

Handling 2-Chloro-5-(difluoromethyl)pyridine requires strict safety measures. Always wear appropriate personal protective equipment (PPE) including gloves, goggles, and lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be handled carefully, using appropriate absorbents, and the incident should be reported to a supervisor. Refer to the Safety Data Sheet (SDS) for detailed handling and safety information.