2-Chloro-5-(difluoromethyl)pyridine(CAS: 71701-99-0)

2-Chloro-5-(difluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 197.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is relatively stable but can react with strong bases or reducing agents under certain conditions.

2-Chloro-5-(difluoromethyl)pyridine can be synthesized via nucleophilic substitution of a chlorinated pyridine with difluoromethyl Grignard reagent. Commonly, this is achieved using a two-step process involving the first formation of a chloropyridine derivative followed by alkylation with a difluoromethyl Grignard reagent.

2-Chloro-5-(difluoromethyl)pyridine is primarily used in the pharmaceutical industry for the synthesis of various drugs, particularly in the development of antiviral compounds. It has also found applications in research and development for materials science and sensor technology.

Handling 2-Chloro-5-(difluoromethyl)pyridine requires strict safety measures. Always wear appropriate personal protective equipment (PPE) including gloves, goggles, and lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be handled carefully, using appropriate absorbents, and the incident should be reported to a supervisor. Refer to the Safety Data Sheet (SDS) for detailed handling and safety information.