6-Chloro-4-methoxynicotinic acid

Basic Information

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CAS Number

716362-10-6

Molecular Formula

C7H6ClNO3

Molecular Weight

187.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

172-175°C

Density

1.430

Refractive Index

1.567

SMILES

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COC1=CC(=NC=C1C(=O)O)Cl

InChI

InChI=1S/C7H6ClNO3/c1-12-5-2-6(8)9-3-4(5)7(10)11/h2-3H,1H3,(H,10,11)

InChIKey

DFXUFJAAXAJWSA-UHFFFAOYSA-N

LogP

1.4418

Topological Polar Surface Area

59.42 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

176

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AM20061461
6-chloro-4-methoxy-pyridine-3-carboxylic acid
6-chloro-4-methoxynicotinic acid
AC-7710
6-Chloro-4-methoxy Nicotinic Acid
SY007902
AKOS005073397
MFCD10000638
6-chloro-4-methoxy-nicotinic acid
6-chloro-4-methoxy-3-pyridinecarboxylic acid, AldrichCPR
SCHEMBL3527742
6-chloro-4-methoxypyridine-3-carboxylic acid
AB55875
J-518570
CS-W003725
716362-10-6
FT-0664763
KD-0738
DTXSID90670357
6-CHLORO-4-METHOXY-3-PYRIDINECARBOXYLIC ACID
EN300-211334
A837267
6-Chloro-4-methoxynicotinic acid
6-Chloro-4-methoxy-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 6-chloro-4-methoxy-

MDL Number

MFCD10000638

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-Chloro-4-methoxynicotinic acid (CAS: 716362-10-6)?

6-Chloro-4-methoxynicotinic acid is a crystalline solid with a molecular weight of approximately 212.61 g/mol. It has a solubility of about 20 mg/mL in water. This compound is moderately reactive, particularly towards nucleophiles. It is stable under normal storage conditions but should be protected from moisture and light.

How is 6-Chloro-4-methoxynicotinic acid (CAS: 716362-10-6) typically synthesized?

6-Chloro-4-methoxynicotinic acid is commonly synthesized via the reaction of 4-methoxynicotinic acid with thionyl chloride. The process typically involves heating the mixture in the presence of a solvent like dichloromethane, yielding the desired product with good selectivity and yield. This method is widely used due to its simplicity and efficiency.

What industries use 6-Chloro-4-methoxynicotinic acid (CAS: 716362-10-6)?

6-Chloro-4-methoxynicotinic acid finds applications in the pharmaceutical industry, particularly in the synthesis of certain drugs. It is also used in the development of sensors and as a precursor in polymer chemistry. Its use in semiconductors and electronics is less common but still relevant.

What precautions should be taken when handling 6-Chloro-4-methoxynicotinic acid (CAS: 716362-10-6)?

When handling 6-Chloro-4-methoxynicotinic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Refer to the Material Safety Data Sheet (MSDS) for detailed information on handling and storage.