6-Chloro-4-methoxynicotinic acid(CAS: 716362-10-6)

6-Chloro-4-methoxynicotinic acid is a crystalline solid with a molecular weight of approximately 212.61 g/mol. It has a solubility of about 20 mg/mL in water. This compound is moderately reactive, particularly towards nucleophiles. It is stable under normal storage conditions but should be protected from moisture and light.

6-Chloro-4-methoxynicotinic acid is commonly synthesized via the reaction of 4-methoxynicotinic acid with thionyl chloride. The process typically involves heating the mixture in the presence of a solvent like dichloromethane, yielding the desired product with good selectivity and yield. This method is widely used due to its simplicity and efficiency.

6-Chloro-4-methoxynicotinic acid finds applications in the pharmaceutical industry, particularly in the synthesis of certain drugs. It is also used in the development of sensors and as a precursor in polymer chemistry. Its use in semiconductors and electronics is less common but still relevant.

When handling 6-Chloro-4-methoxynicotinic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Refer to the Material Safety Data Sheet (MSDS) for detailed information on handling and storage.