4,6-Dichloro-5-methyl-2-pyrimidinamine

Basic Information

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CAS Number

7153-13-1

Molecular Formula

C5H5Cl2N3

Molecular Weight

178.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

354.1°C at 760 mmHg

Density

1.504

Flash Point

168 °C

SMILES

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CC1=C(N=C(N=C1Cl)N)Cl

InChI

InChI=1S/C5H5Cl2N3/c1-2-3(6)9-5(8)10-4(2)7/h1H3,(H2,8,9,10)

InChIKey

ISVBZKXYQWWVPC-UHFFFAOYSA-N

LogP

1.6740199999999998

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

110

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SB57834
MFCD00023253
AC-2394
DTXSID70289300
2-amino-4,6-dicholo-5-methylpyrimidine
NSC-60203
ISVBZKXYQWWVPC-UHFFFAOYSA-N
2-amino-4,6-dichloro-5-methyl-pyrimidine
DS-0300
4,6-Dichloro-5-methyl-pyrimidin-2-ylamine
4,6-dichloro-5-methyl-2-Pyrimidinamine
2-Amino-4,6-dichloro-5-methylpyrimidine
AKOS006346280
BCP07773
7153-13-1
CHEMBL4294140
W-203607
2-Amino-4 pound not6-dichloro-5-methylpyrimidine
FT-0686497
4,6-Dichloro-5-methylpyrimidin-2-amine
SY021278
AC-26607
SCHEMBL4287559
NSC60203
CS-W021555
AMY134
FT-0649232
4,6-dichloro-5-methylpyrimidin-2-amine
4,6-Dichloro-5-methylpyrimidine-2-amine
zlchem 977
PubChem7340

MDL Number

MFCD00023253

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 4,6-Dichloro-5-methyl-2-pyrimidinamine (CAS: 7153-13-1)?

4,6-Dichloro-5-methyl-2-pyrimidinamine is a white crystalline solid with a molecular weight of approximately 221.03 g/mol. It has a bitter taste and is slightly soluble in water. This compound is known for its stability under basic conditions but can be more reactive in acidic environments. It has some reactivity towards nucleophiles and electrophiles, making it useful in various chemical transformations.

How is 4,6-Dichloro-5-methyl-2-pyrimidinamine (CAS: 7153-13-1) typically synthesized?

4,6-Dichloro-5-methyl-2-pyrimidinamine is commonly synthesized via the condensation of 5-methyl-2-pyrimidineamine with chloroacetyl chloride. The reaction is typically carried out in the presence of a base such as sodium hydroxide, with a yield of about 75-85%. The use of a fume hood and appropriate PPE is recommended due to the formation of potentially harmful gases.

What industries use 4,6-Dichloro-5-methyl-2-pyrimidinamine (CAS: 7153-13-1)?

4,6-Dichloro-5-methyl-2-pyrimidinamine is used in the pharmaceutical industry as an intermediate for drug synthesis, particularly in the production of antifungal and antiviral drugs. It also finds applications in the polymer industry for the preparation of functional polymers and in the semiconductor industry as a dopant material.

What precautions should be taken when handling 4,6-Dichloro-5-methyl-2-pyrimidinamine (CAS: 7153-13-1)?

When handling 4,6-Dichloro-5-methyl-2-pyrimidinamine, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during synthesis to minimize exposure to potentially harmful gases. In case of a spill, immediately clean up with care, using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.