4,6-Dichloro-5-methyl-2-pyrimidinamine(CAS: 7153-13-1)

4,6-Dichloro-5-methyl-2-pyrimidinamine is a white crystalline solid with a molecular weight of approximately 221.03 g/mol. It has a bitter taste and is slightly soluble in water. This compound is known for its stability under basic conditions but can be more reactive in acidic environments. It has some reactivity towards nucleophiles and electrophiles, making it useful in various chemical transformations.

4,6-Dichloro-5-methyl-2-pyrimidinamine is commonly synthesized via the condensation of 5-methyl-2-pyrimidineamine with chloroacetyl chloride. The reaction is typically carried out in the presence of a base such as sodium hydroxide, with a yield of about 75-85%. The use of a fume hood and appropriate PPE is recommended due to the formation of potentially harmful gases.

4,6-Dichloro-5-methyl-2-pyrimidinamine is used in the pharmaceutical industry as an intermediate for drug synthesis, particularly in the production of antifungal and antiviral drugs. It also finds applications in the polymer industry for the preparation of functional polymers and in the semiconductor industry as a dopant material.

When handling 4,6-Dichloro-5-methyl-2-pyrimidinamine, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during synthesis to minimize exposure to potentially harmful gases. In case of a spill, immediately clean up with care, using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.