Vinorelbine | CAS No. 71486-22-1

Vinorelbine

Basic Information

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CAS Number

71486-22-1

Molecular Formula

C45H54N4O8

Molecular Weight

778.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Solubility

White to yellow or light brown amorphous powder. MF: C45H54N4O8.2C4H6O6. MW: 1079.12. Aqueous solubility: >1000 mg/ml in distilled water. pH approx 3.5 /Tartrate/

Specific Rotation

D20 +52.4° (c = 0.3 in CHCl3)

SMILES

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CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC

InChI

InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28?,37-,38+,39+,42+,43+,44-,45-/m0/s1

InChIKey

GBABOYUKABKIAF-BXZSYHTRSA-N

LogP

4.753600000000006

Topological Polar Surface Area

133.87 Å²

Hydrogen Bond Donor/Acceptor

2 / 12

Complexity

1690

Safety Information

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Storage Conditions

2-8℃

Toxicity

LD50 in mice (mg/m2): 72 i.v.; 78 orally (Mathé, Reizenstein)

Synonyms & References

English

5'-nor-anhydrovinblastine
CCG-208616
Navelbine base
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-
DTXCID6020640
methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-((6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
SR-05000001504
VINORELBINE [WHO-DD]
AKOS024457606
Navelbin
VINORELBINE TARTRATE IMPURITY J [EP IMPURITY]
Eunades
Vinorelbine (INN)
FT-0657343
HSDB 7665
AB01275493-01
Dihydroxydeoxynorvinkaleukoblastine
EN300-19767066
methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(12S,14R)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3(11),4(9),5,7,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate
methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
Nor-5'-anhydrovinblastine
Vinorelbinum
NSC-760087
CHEBI:480999
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(12S,14R)-16-ethyl-12-methoxycarbonyl-1,10-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
KW-2307 base
Vinorelbinum [Latin]
Navelbine
5' Nor anhydrovinblastine
Exelbine
VINORELBINE [INN]

MDL Number

MFCD00866248

FAQ

What is Vinorelbine (CAS: 71486-22-1)?

Vinorelbine is an alkylating agent used in chemotherapy. It has a chemical formula of C22H26N2O3. Vinorelbine is known for its anti-cancer properties and is used primarily to treat lung and testicular cancers.

What are the main uses of Vinorelbine (CAS: 71486-22-1)?

Vinorelbine is primarily used in the treatment of non-small cell lung cancer and testicular cancer. It is also considered for the treatment of other types of cancer, such as breast cancer, in combination with other drugs.

Is Vinorelbine (CAS: 71486-22-1) safe?

Vinorelbine can cause side effects including nausea, vomiting, hair loss, and bone marrow suppression. It is important to follow safety guidelines, use appropriate protective equipment, and consult healthcare professionals for proper handling and administration to minimize risks.

How should Vinorelbine (CAS: 71486-22-1) be stored?

Vinorelbine should be stored in a tightly closed container in a cool, dry place, away from direct sunlight and heat. The temperature should be maintained between 2°C and 8°C to ensure stability. It should be protected from light and kept out of reach of children.