Aripiprazole Impurity 16

Basic Information

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CAS Number

70500-72-0

Molecular Formula

C9H7NO2

Molecular Weight

161.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

187-192°C

Boiling Point

403.7 °C at 760 mmHg

Flash Point

198 °C

Refractive Index

1.604

SMILES

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Oc1ccc2ccc(=O)[nH]c2c1

InChI

InChI=1S/C9H7NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1-5,11H,(H,10,12)

InChIKey

DBSPUDKBNOZFMX-UHFFFAOYSA-N

LogP

1.2336999999999998

Topological Polar Surface Area

53.089999999999996 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

225

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2,7-Dihydroxyquinoline
7-Hydroxy-2-(1H)-quinolinone
7-Hydroxycarbostyril
7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
2(1H)-Quindinone,3,4-dohydro-7Hydroxy
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
3,4-Dihydro-7-hydroxycarbostyril
7-Hydroxyquinoline-(1H)-2-one
7-HYDROXY-1H-QUINOLIN-2-ONE
7-Hydroxyquinolin-2(1H)-one
7-Hydroxyquinolinone
Quinoline-2,7-diol
7-hydroxy-2-quinolinone
7-hydroxy-2-quinolone
7-hydroxyquinolin-2-one
7-Hydroxy-2(1H)-quinolinone
2(1H)-Quinolinone, 7-hydroxy-
7-HYDROXY-1,2-DIHYDROQUINOLIN-2-ONE
7-hydroxy-quinolone
PubChem5866
7-hydroxyhydroquinolin-2-one
7-Hydroxy-2(1H)-quinolone
QUI074
7-oxidanyl-1H-quinolin-2-one
7-Hydroxyquinoline-(1H)-2
7-hydroxy-1,2-dihydroquinolin-2-one
7-hydroxyquinolin-2(1H)-one

MDL Number

MFCD04117979

FAQ

What is Aripiprazole Impurity 16 (CAS: 70500-72-0)?

Aripiprazole Impurity 16 (CAS: 70500-72-0) is a chemical compound identified as a specific byproduct or degradation product of aripiprazole, a second-generation antipsychotic medication. It is structurally related to aripiprazole but differs in molecular configuration, often arising during synthesis or storage. Its chemical formula is typically C19H25NO2, with properties such as solubility in organic solvents and a molecular weight of approximately 303.4 g/mol. This impurity is primarily of interest in pharmaceutical quality control and research for ensuring drug purity and safety.

What are the main uses of Aripiprazole Impurity 16 (CAS: 70500-72-0)?

Aripiprazole Impurity 16 (CAS: 70500-72-0) is mainly used in pharmaceutical research to identify and quantify impurities in aripiprazole production. It plays a critical role in drug development, regulatory compliance, and analytical testing to ensure product consistency and adherence to safety standards. Additionally, it is utilized in the study of degradation pathways and stability testing of pharmaceutical formulations. Its applications are focused on quality assurance within the pharmaceutical industry.

Is Aripiprazole Impurity 16 (CAS: 70500-72-0) safe?

Aripiprazole Impurity 16 (CAS: 70500-72-0) is not intended for therapeutic use and is primarily handled in controlled laboratory environments. While its toxicity profile is less studied compared to aripiprazole, it may pose health risks if exposed in high concentrations. Proper safety measures, such as using personal protective equipment (PPE) and ensuring adequate ventilation, are recommended during handling. Compliance with standard safety protocols and regulatory guidelines is essential to mitigate potential hazards in pharmaceutical settings.

How should Aripiprazole Impurity 16 (CAS: 70500-72-0) be stored?

Aripiprazole Impurity 16 (CAS: 70500-72-0) should be stored in a sealed, cool, and dry environment, away from light and moisture. It is typically kept at temperatures below 25°C (77°F) and humidity levels under 60% to maintain stability. Storage in airtight containers made of glass or high-density polyethylene (HDPE) is recommended. Avoid exposure to strong oxidizing agents or heat sources to prevent degradation. Proper labeling and storage conditions are crucial for preserving its chemical integrity and ensuring safe handling.