1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid

Basic Information

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CAS Number

70458-96-7

Molecular Formula

C16H18FN3O3

Molecular Weight

319.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

221°C

Boiling Point

695.6°C at 760 mmHg

Density

1.2504 (estimate)

Water Solubility

Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water

Flash Point

289.9 °C

Vapor Pressure

0.0±1.6 mmHg at 25°C

SMILES

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CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChIKey

OGJPXUAPXNRGGI-UHFFFAOYSA-N

LogP

1.2683000000000002

pKa

pKa1 6.34; pKa2 8.75(at 25℃)

Topological Polar Surface Area

74.57000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

519

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Toxicity

LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura)

Synonyms & References

English

norfloxacin
1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica
1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid
Norfloxacine
1-ethyl-6-fluoro-4-oxo-7-piperazinyl-1,4-dihydro-quinoline-3-carboxylic acid
1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
4803P
am-715
Barazan
Fulgram
GMP
Noflo
noroxin
Utinor
WAKO149-08241
Zomxin
Zoroxin
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
Baccidal
Chibroxin
Floxacin 400
Norphloxacine
N-Desmethylpefloxacin
Sebercim
Norfloxacinum
Norfloxacino
Lexinor
NFLX
Norfloxacine [INN-French]
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Norfloxacinum [INN-Latin]

MDL Number

MFCD00079532

Customs Code

2933990090

FAQ

What is 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-96-7)?

1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-96-7) is a synthetic organic compound with a complex structure featuring a quinoline ring, piperazine group, and fluorine substitution. It is a white crystalline solid with moderate solubility in polar solvents. The molecule exhibits specific pharmacological activity due to its quinoline core and piperazine functionality, making it relevant in drug discovery and chemical research. Its chemical formula is C14H16FN3O2, with molecular weight 287.3 g/mol.

What are the main uses of 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-96-7)?

This compound is primarily used in pharmaceutical research as a potential drug candidate for neurological disorders. It serves as an intermediate in the synthesis of bioactive molecules targeting central nervous system (CNS) pathways. Additionally, it is applied in chemical synthesis for developing therapeutic agents and in medicinal chemistry studies. Its unique structure makes it valuable for exploring new treatments and understanding molecular interactions in drug development.

Is 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-96-7) safe?

Safety of this compound depends on its application. As a research chemical, it requires careful handling to avoid skin contact, inhalation, or ingestion. Limited toxicity data exists, but standard lab safety protocols—such as wearing protective gear and ensuring proper ventilation—should be followed. It is not approved for direct consumer use and must adhere to industrial safety standards for handling hazardous materials. Always consult safety data sheets (SDS) for specific guidelines.

How should 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-96-7) be stored?

Store this compound in a sealed, cool (2-8°C), and dry environment, away from light and moisture. Keep in airtight containers to prevent degradation or contamination. Avoid exposure to air and humidity to maintain stability. For long-term storage, use a desiccator or refrigerated conditions. Always check manufacturer guidelines for specific storage requirements and ensure proper labeling for safe handling.