2-(Difluoromethyl)ornithine hydrochloride (1:1) | CAS No. 70050-56-5

2-(Difluoromethyl)ornithine hydrochloride (1:1)

Basic Information

CAS Number

70050-56-5

Molecular Formula

C6H13ClF2N2O2

Molecular Weight

218.63 g/mol

AD

Basic Physical Properties

Melting Point

181-184 ºC

C(CC(C(F)F)(C(=O)O)N)CN

InChI

InChI=1S/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H

InChIKey

VKDGNNYJFSHYKD-UHFFFAOYSA-N

LogP

0.19430000000000042

Topological Polar Surface Area

89.33999999999999 Ų

Hydrogen Bond Donor/Acceptor

5 / 4

Complexity

166

Synonyms & References

English

  • Eflornithine [INN:BAN]
  • Eflornithinum [Latin]
  • DTXCID70467
  • alpha-difluoromethyl-dl-ornithine
  • AKOS006281180
  • DL-.alpha.-Difluoromethylornithine
  • NSC337250
  • C07997
  • SDCCGSBI-0050414.P002
  • D11AX16
  • MFCD00221766
  • BDBM50028197
  • 2-(difluoromethyl)-2,5-diaminopentanoic acid;
  • RFI 7178
  • RMI 71782
  • DFMO (growth regulator)
  • alpha-Difluoromethylornithine
  • NCGC00015316-02
  • alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid
  • UNII-ZQN1G5V6SR
  • CHEBI:41948
  • Eflornithinum
  • Difluromethylornithine
  • 2-difluoromethyl-2,5-diaminopentanoic acid
  • Ornidyl
  • DL-alpha-Difluoromethylornithine
  • 70052-12-9 (free base)
  • BCP10516
  • 2,5-diamino-2-(difluoromethyl)pentanoic acid.
  • EFLORNITHINE [EMA EPAR]
  • NCGC00015316-06

FAQ

What are the physical and chemical properties of 2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5)?

2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5) is a crystalline solid with a molecular weight of approximately 261.58 g/mol. It has a high solubility in water and low solubility in organic solvents. This compound is moderately reactive, particularly with nucleophiles. It is a hydrochloride salt, which affects its solubility and reactivity profile.

How is 2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5) typically synthesized?

2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5) is typically synthesized via the amidation of 2-(difluoromethyl)ornithine with hydrochloric acid. The reaction is carried out in the presence of an appropriate solvent and a catalyst to ensure high selectivity and yield. The exact method can vary based on the specific requirements of the synthesis.

What industries use 2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5)?

2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5) is primarily used in the pharmaceutical industry for the development of novel drugs. It also has applications in the polymer industry for the synthesis of advanced materials and in the semiconductor industry for electronic applications. Additionally, it can be used in the sensor technology industry for specific detection purposes.

What precautions should be taken when handling 2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5)?

Proper personal protective equipment (PPE) should be worn when handling 2-(Difluoromethyl)ornithine hydrochloride (CAS: 70050-56-5), including gloves, safety goggles, and a lab coat. The reaction should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.

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