2-Amino-2-phenylacetamide

Basic Information

View in Editor

CAS Number

700-63-0

Molecular Formula

C8H10N2O

Molecular Weight

150.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

128.0 to 132.0 deg-C

Density

1.178±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

View in Editor

C1=CC=C(C=C1)C(C(=O)N)N

InChI

InChI=1S/C8H10N2O/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H2,10,11)

InChIKey

KIYRSYYOVDHSPG-UHFFFAOYSA-N

LogP

0.17170000000000007

Topological Polar Surface Area

69.11 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

141

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

2-Amino-2-phenylacetamide
2-azanyl-2-phenyl-ethanamide
NSC47695
MFCD06799064
d-phenylglycine amide
BRN 0972472
alpha-Amino-benzeneacetamide
1-14-00-00592 (Beilstein Handbook Reference)
SY009237
P2402
AS-58496
Z57204607
ACETAMIDE, 2-AMINO-2-PHENYL-
2-Amino-2-phenyl-acetamide
Benzeneacetamide, .alpha.-amino-
NS00079555
SY017679
AC-684
FT-0636162
DL-2-PHENYLGLYCINAMIDE
EINECS 211-849-3
SCHEMBL544671
H-Phg-NH2
DTXSID20863871
EN300-25412
Benzeneacetamide, alpha-amino-
H-Phg-NH HCl
FT-0688396
AKOS000204934
AKOS037748796
J-501016

MDL Number

MFCD00025498

FAQ

What are the physical and chemical properties of 2-Amino-2-phenylacetamide (CAS: 700-63-0)?

2-Amino-2-phenylacetamide (CAS: 700-63-0) is a white to off-white solid with a molecular weight of approximately 184.23 g/mol. It is sparingly soluble in water but readily soluble in organic solvents like dichloromethane and ethanol. The compound is moderately reactive, particularly susceptible to hydrolysis in the presence of acids or bases. It exhibits basic properties due to the amino group and can react with acids to form salts.

How is 2-Amino-2-phenylacetamide (CAS: 700-63-0) typically synthesized?

2-Amino-2-phenylacetamide (CAS: 700-63-0) is commonly synthesized via the condensation of phenylacetic acid with ammonia in the presence of a weak base like sodium carbonate. This reaction proceeds via an intermediate imine which subsequently reduces to form the desired amide. The process yields a high purity product with good selectivity and reproducibility.

What industries use 2-Amino-2-phenylacetamide (CAS: 700-63-0)?

2-Amino-2-phenylacetamide (CAS: 700-63-0) finds applications in the pharmaceutical industry, where it serves as a precursor for the synthesis of various drugs. It is also utilized in the polymer industry for the production of advanced polymers with enhanced properties. Additionally, it has been explored for use in sensor technology and semiconductor manufacturing due to its unique chemical characteristics.

What precautions should be taken when handling 2-Amino-2-phenylacetamide (CAS: 700-63-0)?

When handling 2-Amino-2-phenylacetamide (CAS: 700-63-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should always be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be immediately cleaned up with absorbent material, followed by thorough rinsing of the area. Refer to the Safety Data Sheet (SDS) for detailed instructions on handling and disposal of this compound.