Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate | CAS No. 691856-86-7
Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate
Basic Information
CAS Number
691856-86-7
Molecular Formula
C17H13FO4
Molecular Weight
300.29 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 3-Benzofurancarboxylic acid, 2-(4-fluorophenyl)-5-hydroxy-, ethyl ester
- PCOIFIVNARQEPO-UHFFFAOYSA-N
- 691856-86-7
- SY338112
- ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate
- ethyl 2-(4-fluorophenyl)-5-hydroxybenzo[b]furan-3-carboxylate
- 2-(4-FLUORO-PHENYL)-5-HYDROXY-BENZOFURAN-3-CARBOXYLIC ACID ETHYL ESTER
- DTXSID40717862
- A922915
- FT-0720810
- MFCD18073883
- SCHEMBL1918033
- ethyl2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate
- CS-M1522
- 2-(4-Fluorophenyl)-5-hydroxybenzofuran-3-carboxylic acid ethyl ester
- 2-(4-Fluorophenyl)-5-hydroxy-3-benzofurancarboxylic acid ethyl ester
- Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate
- CS-13949
- AKOS027323788
- 2-(4-fluorophenyl)-5-hydroxy-3-Benzofurancarboxylic acid ethyl ester
MDL Number
MFCD18073883
FAQ
What are the physical and chemical properties of Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate (CAS: 691856-86-7)?
Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate is a crystalline compound with a molecular weight of approximately 288.2 g/mol. Its solubility in water is low, around 0.1 g/100 mL. It is highly reactive towards nucleophiles and can undergo hydrolysis under basic conditions. This compound is stable under acidic conditions but should be handled in a fume hood to avoid exposure to air and moisture.
How is Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate (CAS: 691856-86-7) typically synthesized?
Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate is typically synthesized via a multistep process involving the synthesis of 4-fluorophenylacetic acid, its esterification with ethyl bromide, followed by benzylation and condensation reactions. Commonly used catalysts include sulfuric acid or phosphoryl chloride. The final product shows high selectivity and yield, making it suitable for further medicinal chemistry applications.
What industries use Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate (CAS: 691856-86-7)?
Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate finds application in the pharmaceutical industry for the development of new drugs, particularly in cancer research and treatment. It is also used in the synthesis of sensor materials and as a building block in the development of novel materials such as polymers and semiconductors.
What precautions should be taken when handling Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate (CAS: 691856-86-7)?
When handling Ethyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from moisture and heat sources. Handling should be conducted in a fume hood to minimize exposure, and in case of a spill, it should be cleaned up carefully following standard laboratory procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.
Related Compounds
![[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure](https://static.chemtradehub.com/structs/124/1247703-29-2-3e8f.webp "[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure")
![(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure](https://static.chemtradehub.com/structs/139/139264-69-0-da9c.webp "(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure")
(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol
CAS Number:
139264-69-0
Molecular Formula:
C15H23N3O
![2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure](https://static.chemtradehub.com/structs/143/1431511-18-0-164b.webp "2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure")
2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
CAS Number:
1431511-18-0
Molecular Formula:
C30H41NO7
![3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure](https://static.chemtradehub.com/structs/144/144486-08-8-1df1.webp "3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure")
3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one
CAS Number:
144486-08-8
Molecular Formula:
C11H9N3O
![(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure](https://static.chemtradehub.com/structs/147/147852-78-6-0a74.webp "(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure")
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