6-methoxypyrazin-2-amine

Basic Information

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CAS Number

6905-47-1

Molecular Formula

C5H7N3O

Molecular Weight

125.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

112 ºC (cyclohexane )

Boiling Point

266.1±35.0 ºC (760 Torr),

Density

1.224±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

114.8±25.9 ºC,

SMILES

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COC1=NC(=CN=C1)N

InChI

InChI=1S/C5H7N3O/c1-9-5-3-7-2-4(6)8-5/h2-3H,1H3,(H2,6,8)

InChIKey

YGFNVCMGUHJLRU-UHFFFAOYSA-N

LogP

0.06740000000000002

Topological Polar Surface Area

61.03 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

88.3

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AMY5640
AKOS005146121
MFCD09909689
6-(methyloxy)-2-pyrazinamine
DTXSID00406669
6-METHOXYPYRAZINAMINE
(R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dionecyclic16,17-acetalwithcyclohexanecarboxaldehyde21-isobutyrate
SCHEMBL1011504
DS-10480
pyrazinamine, 6-methoxy-
6-Methoxy-pyrazin-2-ylamine
2-AMINO-6-METHOXYPYRAZINE
AC-31898
SY010731
Z1198261569
A9155
6905-47-1
AB54770
CS-W013517
EN300-129555
YGFNVCMGUHJLRU-UHFFFAOYSA-N
2-Amino-6-methoxypyrazine, 95%
J-518860
6-methoxypyrazin-2-amine
2-Amino-6-methoxy-pyrazine
FT-0696100
2-Amino-6-methoxypyrazine
6-methoxy-2-Pyrazinamine
6-Methoxypyrazinamine
2-PYRAZINAMINE, 6-METHOXY-
PubChem17504

MDL Number

MFCD09909689

FAQ

What are the physical and chemical properties of 6-methoxypyrazin-2-amine (CAS: 6905-47-1)?

6-methoxypyrazin-2-amine (CAS: 6905-47-1) is a crystalline compound with a molecular weight of approximately 127.14 g/mol. It is slightly soluble in water and has a pKa of around 6.0. The compound shows moderate reactivity towards nucleophiles and is stable under normal conditions but can undergo hydrolysis in basic media.

How is 6-methoxypyrazin-2-amine (CAS: 6905-47-1) typically synthesized?

6-methoxypyrazin-2-amine can be synthesized through the reaction of 6-methylpyrazine with methanol in the presence of a suitable catalyst such as potassium hydroxide. The reaction proceeds via a nucleophilic substitution mechanism, yielding the amine with good selectivity and moderate yield (60-70%).

What industries use 6-methoxypyrazin-2-amine (CAS: 6905-47-1)?

6-methoxypyrazin-2-amine is used in the pharmaceutical industry as a precursor for the synthesis of certain drug candidates. It also finds applications in the food industry as a flavor enhancer and in the polymer industry as a stabilizer. Additionally, it is used in the development of sensors and semiconductors.

What precautions should be taken when handling 6-methoxypyrazin-2-amine (CAS: 6905-47-1)?

When handling 6-methoxypyrazin-2-amine (CAS: 6905-47-1), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably a fume hood. Spills should be cleaned up carefully using absorbent materials and appropriate waste disposal methods. Always consult the Safety Data Sheet (SDS) for detailed safety information.