2-Fluoro-5-(trifluoromethyl)pyridine

Basic Information

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CAS Number

69045-82-5

Molecular Formula

C6H3F4N

Molecular Weight

165.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

120°C

Density

1.368

Flash Point

32 ℃(89.6 ℉)(lit.)

Refractive Index

1.401

SMILES

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C1=CC(=NC=C1C(F)(F)F)F

InChI

InChI=1S/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

InChIKey

UUODQIKUTGWMPT-UHFFFAOYSA-N

LogP

2.2394999999999996

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

133

Safety Information

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GHS Hazard Pictograms

H226

H317

H412

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H317 May cause an allergic skin reaction
Sensitization, Skin

H412 Harmful to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 3 Class 3

Synonyms & References

English

CS-W016077
NS00003692
PS-6614
AKOS005064009
FT-0646482
2-Fluoro-5-(trifluoromethyl)pyridine
Pyridine, 2-fluoro-5-(trifluoromethyl)-
Q-101457
resorcinoldiglycidylether
DTXSID10420174
2-fluoro-5-trifluoromethyl-pyridine
AC-23341
EC 400-290-2
AM62414
A9151
69045-82-5
SCHEMBL8522
EN300-119843
MFCD07437945
2-Fluoro-5-trifluoromethylpyridine
AB41967
F0846
2-Fluoro-5-(trifluoromethyl)pyridine, 97%
2-Fluoro-5-trifluoromethyl pyridine
C6H3F4N
3-Fluoropyridine
6-fluoro-3-trifluoromethylpyridine
AC1NUYHS
AG-G-68276
PubChem9252
SBB054394

MDL Number

MFCD07437945

FAQ

What are the physical and chemical properties of 2-Fluoro-5-(trifluoromethyl)pyridine (CAS: 69045-82-5)?

2-Fluoro-5-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 217.03 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and chloroform. The compound is known for its high reactivity, particularly in nucleophilic substitution reactions. It is also thermally stable under normal conditions but can decompose at elevated temperatures.

How is 2-Fluoro-5-(trifluoromethyl)pyridine (CAS: 69045-82-5) typically synthesized?

2-Fluoro-5-(trifluoromethyl)pyridine is typically synthesized through the reaction of 5-chloro-2-fluoropyridine with a trifluoromethylating agent like triflic anhydride in the presence of a base. This process provides good yield and selectivity, with the reaction being monitored by GC (gas chromatography) to ensure purity. The use of appropriate catalysts and precursors is essential for achieving high purity products.

What industries use 2-Fluoro-5-(trifluoromethyl)pyridine (CAS: 69045-82-5)?

2-Fluoro-5-(trifluoromethyl)pyridine finds application in various industries. It is used in the pharmaceutical sector for the synthesis of certain medications. In the polymer industry, it is a key component in the development of advanced materials. Additionally, it is utilized in the production of sensors and as a precursor in semiconductor manufacturing due to its unique chemical properties.

What precautions should be taken when handling 2-Fluoro-5-(trifluoromethyl)pyridine (CAS: 69045-82-5)?

When handling 2-Fluoro-5-(trifluoromethyl)pyridine, it is crucial to wear personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or in a fume hood to avoid inhalation of vapors. Proper spill handling procedures should be followed, and the Material Safety Data Sheet (MSDS) should be readily available. This compound can be toxic if ingested, so spills should be cleaned up immediately and the area should be thoroughly ventilated.