2-Chloro-5-(trichloromethyl)pyridine

Basic Information

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CAS Number

69045-78-9

Molecular Formula

C6H3Cl4N

Molecular Weight

230.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

53-55ºC

Boiling Point

281.8 °C at 760 mmHg

Density

1.582

Flash Point

151.2 °C

Refractive Index

1.575

SMILES

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C1=CC(=NC=C1C(Cl)(Cl)Cl)Cl

InChI

InChI=1S/C6H3Cl4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

InChIKey

VLJIVLGVKMTBOD-UHFFFAOYSA-N

LogP

3.5617

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

133

Safety Information

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Hazard Statement

Synonyms & References

English

Z57107671
MFCD00160145
2-chloro-5-trichloromethylpyridine, AldrichCPR
AKOS000268273
Pyridine, 2-chloro-5-(trichloromethyl)-
CHEMBL3188409
2-chloro-5-(Trichloromethyl)-pyridine
2-Chloro-5-trichloromethyl pyridine
NS00004956
Tox21_301246
UNII-7YHC64YM0S
CAS-69045-78-9
P10088
Q27269026
2-CHLORO-5-TRICHLOROMETHYLPYRIDINE
DK-0013
A9149
AB04207
69045-78-9
DTXSID4028967
FT-0641218
SY014936
2-chloro-5-trichloromehtylpyridine
AC-23343
AMY5198
2-chloro-5-(trichloromethyl)pyridine
EU-0033517
CS-0051963
EN300-25485
NCGC00255192-01
VLJIVLGVKMTBOD-UHFFFAOYSA-N

MDL Number

MFCD00160145

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9)?

2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9) is a crystalline solid with a molecular weight of approximately 293.95 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and dichloromethane. The compound is highly reactive due to the presence of electron-withdrawing groups, making it prone to nucleophilic substitution reactions.

How is 2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9) typically synthesized?

2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9) can be synthesized via the condensation of 2-chloropyridine with trichloromethyl chlorides. The reaction is typically carried out in the presence of a Lewis acid catalyst such as aluminum chloride, leading to a high yield and good selectivity.

What industries use 2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9)?

2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the development of sensors and as a precursor in the production of polymers, though its primary application is in specialty chemical manufacturing.

What precautions should be taken when handling 2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9)?

When handling 2-Chloro-5-(trichloromethyl)pyridine (CAS: 69045-78-9), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a respirator. The substance should be handled in a well-ventilated area or a fume hood. In case of a spill, avoid direct contact and clean up using appropriate procedures as outlined in the Safety Data Sheet (SDS).