N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine

Basic Information

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CAS Number

68858-20-8

Molecular Formula

C20H21NO4

Molecular Weight

339.39 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

144.0 to 147.0 deg-C

Boiling Point

551.8°C at 760 mmHg

Density

1.2270 (rough estimate)

Flash Point

287.5℃

Solubility

Solubility in methanol gives very faint turbidity.

Refractive Index

-17.5 ° (C=1, DMF)

Specific Rotation

-16 º (c=1,DMF)

SMILES

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CC(C)C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C20H21NO4/c1-12(2)18(19(22)23)21-20(24)25-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17-18H,11H2,1-2H3,(H,21,24)(H,22,23)/t18-/m0/s1

InChIKey

UGNIYGNGCNXHTR-SFHVURJKSA-N

LogP

3.6343000000000014

Topological Polar Surface Area

75.63 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

470

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

HY-I1111
EN300-81244
L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
CHEMBL560019
68858-20-8
J-300298
AM82369
AC-24054
F0299
BP-10148
M03378
Fmoc-L-Val-OH
NS00062773
AKOS015924209
L-Valine, N-FMOC protected
(((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine
CS-W009099
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoic acid
N-Fmoc-L-valine
MFCD00037124
(S)-2-((((9H-FLUOREN-9-YL)METHOXY)CARBONYL)AMINO)-3-METHYLBUTANOIC ACID
Fmoc-L-valine
FMOC-VALINE
AKOS010397808
N-(9-Fluorenylmethoxycarbonyl)-L-valine-15N
STR09734
9-Fluorenylmethyloxycarbonyl-L-valine
SCHEMBL120703
Fmoc-Val-OH
N-(9-Fluorenylmethoxycarbonyl)-L-valine
SY014934

MDL Number

MFCD00037124

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) is a protected amino acid derivative used in organic synthesis. It contains a fluorene ring linked to a valine residue via a carbonyl group, with an N-methoxy carbonyl protecting group. This compound is valued for its stability and utility in pharmaceutical and biochemical research due to its ability to prevent side reactions during synthesis.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) is primarily used in peptide synthesis and drug development. Its protected structure makes it a key intermediate in creating bioactive molecules for pharmaceutical applications, particularly in targeting metabolic and neurological disorders. It also finds use in bioconjugate chemistry and as a building block for chiral compounds in research settings.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) is generally safe when handled according to standard chemical safety protocols. However, it may cause mild irritation to skin and eyes, so protective measures like gloves and goggles are recommended. Always follow safety guidelines and consult the safety data sheet (SDS) for detailed information on its handling and potential risks.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine (CAS: 68858-20-8) should be stored in a cool, dry, and light-protected environment. Keep in a sealed container to prevent moisture exposure, which can degrade its chemical stability. Storage at 2-8°C is optimal, and it should be kept away from incompatible substances to maintain its integrity for research or pharmaceutical applications.