Ceftizoxime sodium

Basic Information

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CAS Number

68401-82-1

Molecular Formula

C13H12N5NaO5S2

Molecular Weight

405.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

227℃

Water Solubility

Soluble in water

Solubility

DMSO: soluble1mg/mL

SMILES

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CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)[O-].[Na+]

InChI

InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1

InChIKey

ADLFUPFRVXCDMO-LIGXYSTNSA-M

LogP

-0.98050

Complexity

675

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 in mice, rats (mg/kg): ~6000 i.v. (Fukuhara)

Synonyms & References

English

Ceftizoxime Monosodium Salt
Cefizox (TN)
FR-13749
UNII-26337D5X88
CEFTIZOXIME SODIUM [WHO-DD]
Monosodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetylamino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
NCGC00167460-01
FK 749
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)-(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6-alpha,7-beta(Z)))-
SKF 88373-Z
CEFTIZOXIME SODIUM SALT [MI]
Epocelin (TN)
sodium 7beta-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-2,3-didehydropenam-2-carboxylate
SK&F 88373-Z
CEFTIZOXIME SODIUM [USAN]
C08118
Ceftizoxime sodium (JP17/USP)
Cefizox
Ceftizoxime sodium salt
SK&F-88373-Z
CEFTIZOXIME SODIUM [ORANGE BOOK]
CAS-68401-82-1
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2,3-dihydro-2-imino-4-thiazoly)(methoxyimino)acetyl]amino]-8-oxomonosodium salt
Ceftizoxim-natrium [German]
68401-82-1
CZX
CS-5309
Sodium, Ceftizoxime
CEFTIZOXIME SODIUM
DTXCID3026643
Ceftizoxime (sodium)

MDL Number

MFCD01682036

Customs Code

2941905990

FAQ

What is Ceftizoxime sodium (CAS: 68401-82-1)?

Ceftizoxime sodium (CAS: 68401-82-1) is a third-generation cephalosporin antibiotic used to treat bacterial infections. Its chemical formula is C16H16N5O7S2Na, with a molecular weight of 473.5 g/mol. It is highly soluble in water, making it suitable for injectable formulations. The compound exhibits broad-spectrum activity against Gram-negative bacteria and is structurally characterized by its 3-ethoxy-1-(4-hydroxyphenyl)propyl side chain, enhancing its efficacy and stability in pharmaceutical applications.

What are the main uses of Ceftizoxime sodium (CAS: 68401-82-1)?

Ceftizoxime sodium (CAS: 68401-82-1) is primarily used in pharmaceuticals to combat severe bacterial infections, including respiratory tract, urinary tract, and skin infections. It targets Gram-negative pathogens such as *E. coli* and *K. pneumoniae*. In veterinary medicine, it is employed for livestock treatments. Its broad-spectrum activity and stability make it a key component in antibiotic therapies, particularly in cases resistant to other medications. Additionally, it is used in research for studying antimicrobial mechanisms.

Is Ceftizoxime sodium (CAS: 68401-82-1) safe?

Ceftizoxime sodium (CAS: 68401-82-1) is considered safe when administered as directed, but it may cause side effects such as allergic reactions, gastrointestinal discomfort, or superinfections. Handling precautions include wearing gloves and avoiding contact with eyes. It is approved by regulatory bodies like the FDA for medical use, and safety standards emphasize proper disposal to prevent environmental contamination. Always consult healthcare professionals for appropriate usage and risk assessment.

How should Ceftizoxime sodium (CAS: 68401-82-1) be stored?

Ceftizoxime sodium (CAS: 68401-82-1) should be stored in a cool, dry place at 2-8°C (36-46°F) to maintain stability and potency. Protect from light and moisture by using airtight containers. Avoid exposure to extreme temperatures or humidity to prevent degradation. The compound has a shelf life of up to 24 months when unopened and properly stored, ensuring long-term efficacy in pharmaceutical and research settings.