Arotinolol HCl

Basic Information

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CAS Number

68377-91-3

Molecular Formula

C15H22ClN3O2S3

Molecular Weight

408.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

236°C(dec.)

Boiling Point

599.8°Cat760mmHg

Density

1.35

Flash Point

316.6°C

Refractive Index

1.646

SMILES

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CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O.Cl

InChI

InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

InChIKey

XXDAXBZYUXLDRD-UHFFFAOYSA-N

LogP

3.2334000000000005

Topological Polar Surface Area

88.24000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 5

Complexity

406

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)

Synonyms & References

English

FT-0602864
arotinolol hydrochloride
AKOS027384237
CAS-68377-91-3
Arotinolol Hydrochloride,(S)-
D01830
Q27272409
5-[2-[[3-(tert-Butylamino)-2-hydroxypropyl]thio]thiazol-4-yl]thiophene-2-carboxamide Hydrochloride
(+/-)-2-(3'-TERT-BUTYLAMINO-2'-HYDROXYPROPYLTHIO)-4-(5'-CARBAMOYL-2'-THIENYL)THIAZOLE HCL
2-THIOPHENECARBOXAMIDE, 5-(2-((3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPYL)THIO)-4-THIAZOLYL)-, MONOHYDROCHLORIDE, (+/-)-
S-596
68377-91-3
5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide;hydrochloride
arotinololhydrochloride
AROTINOLOL HYDROCHLORIDE [MART.]
9DOI1HT306
SCHEMBL348620
Arotinolol hydrochloride (JP17)
Arotinolol (hydrochloride)
DTXCID9026849
BCP06721
2-Thiophenecarboxamide, 5-(2-((3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)thio)-4-thiazolyl)-, monohydrochloride, (+-)-
Tox21_112721
AROTINOLOL HYDROCHLORIDE [WHO-DD]
F20661
Arotinolol HCl;(S)-arotinolol hydrochloride
NCGC00181107-01
Arotinolol hydrochloride [JAN]
Almarl (TN)
CHEBI:31239
UNII-9DOI1HT306

MDL Number

MFCD00941421

FAQ

What is Arotinolol HCl (CAS: 68377-91-3)?

Arotinolol HCl is a hydrochloride salt of arotinolol, a non-selective beta-adrenergic antagonist used in the treatment of hypertension and certain heart conditions. It has the chemical formula C15H17ClN2O2. This compound is characterized by its ability to block the effects of catecholamines on the heart and blood vessels, thereby reducing blood pressure and heart rate.

What are the main uses of Arotinolol HCl (CAS: 68377-91-3)?

Arotinolol HCl is primarily used in the pharmaceutical industry for the treatment of hypertension and certain heart conditions. It is often prescribed to manage symptoms associated with cardiac arrhythmias and to reduce the risk of complications in patients with congestive heart failure. Additionally, it can be used in combination with other medications to achieve better blood pressure control.

Is Arotinolol HCl (CAS: 68377-91-3) safe?

Arotinolol HCl is generally considered safe when used as directed by a healthcare professional. However, it is important to follow prescribed dosages and be aware of potential side effects such as dizziness, fatigue, and bradycardia. Patients should avoid driving or operating heavy machinery until they know how this medication affects them. Proper use and adherence to medical advice are crucial for safety.

How should Arotinolol HCl (CAS: 68377-91-3) be stored?

Arotinolol HCl should be stored at room temperature (15-30°C) away from direct sunlight and moisture. It should be kept in a tightly closed container to protect it from air and light. Avoid storing it in humid or damp conditions, as this can affect its stability. It is important to keep it out of reach of children and pets. Always follow the storage instructions provided by the manufacturer to ensure the medication's efficacy and safety.