Azathioprine EP Impurity F (Didanosine EP Impurity A, Didanosine USP Related Compound A, Hypoxanthine)

Basic Information

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CAS Number

68-94-0

Molecular Formula

C5H4N4O

Molecular Weight

136.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

Powder

Melting Point

>300 °C

Boiling Point

533.4°C at 760 mmHg

Density

1.4295 (rough estimate)

Flash Point

276.4 °C

Solubility

1 M NaOH: 25 mg/mL

Refractive Index

1.8500 (estimate)

SMILES

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C1=NC2=C(N1)C(=O)NC=N2

InChI

InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChIKey

FDGQSTZJBFJUBT-UHFFFAOYSA-N

LogP

-0.35380000000000006

pKa

8.7(at 25℃)

Topological Polar Surface Area

74.43 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

190

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

GTPL4555
Hypoxsanthine (1,7-Dihydro-6H-purin-6-one)
DivK1c_006557
Epitope ID:167471
2TN51YD919
6-Oxopurine
4-Hydroxy-1H-purine
AKOS009159101
AC-32451
AG-670/31547063
FT-0670251
MERCAPTOPURINE IMPURITY, HYPOXANTHINE- [EP IMPURITY]
DIDANOSINE IMPURITY A [EP IMPURITY]
Z1954805546
AKOS022168213
6H-Purin-6-one, 1,9-dihydro-
CAS_790
AKOS000267572
NCGC00095622-01
KBio1_001501
HY-N0091
3h-hypoxanthine
6,7-dihydro-3H-purin-6-one
BCP22929
6-Hydroxypurine; Purin-6-ol; Sarcine
SDCCGMLS-0065594.P001
Discontinued. See H998503 or H998504
1H,7H-Hypoxanthine
DIDANOSINE IMPURITY A
NSC 14665
1,7-Dihydro-6H-purin-6-one (Hypoxanthine)

MDL Number

MFCD00005725

Customs Code

2933990090

FAQ

What is Azathioprine EP Impurity F (CAS: 68-94-0)?

Azathioprine EP Impurity F (CAS 68-94-0), also known as Hypoxanthine, is a purine nucleoside analog. It has the chemical formula C5H4N4O2 and appears as a white crystalline powder. This compound is commonly used as an impurity in pharmaceutical quality control and is structurally related to azathioprine and didanosine.

What are the main uses of Azathioprine EP Impurity F (CAS: 68-94-0)?

Azathioprine EP Impurity F (CAS 68-94-0) serves as a critical component in pharmaceutical research, particularly for analyzing impurities in drugs like azathioprine and didanosine. It is also used in chemical synthesis and as a reference standard in drug development, ensuring product purity and compliance with EP and USP specifications.

Is Azathioprine EP Impurity F (CAS: 68-94-0) safe?

Azathioprine EP Impurity F (CAS 68-94-0) is generally considered safe in controlled pharmaceutical settings. However, handling should follow standard safety protocols to avoid inhalation or skin contact. Safety data indicates low toxicity at typical exposure levels, but proper protective measures are recommended during storage and use to ensure compliance with regulatory standards.

How should Azathioprine EP Impurity F (CAS: 68-94-0) be stored?

Azathioprine EP Impurity F (CAS 68-94-0) should be stored in a cool, dry, and dark place, preferably at 2-8°C. It requires airtight containers to prevent moisture absorption and degradation. Avoid exposure to light and maintain stable humidity levels to preserve its chemical integrity and prolong shelf life.