Nutlin-3a | CAS No. 675576-98-4

Nutlin-3a

Basic Information

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CAS Number

675576-98-4

Molecular Formula

C30H30Cl2N4O4

Molecular Weight

581.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.36

Solubility

DMSO: soluble5mg/mL, clear

SMILES

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CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI

InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

InChIKey

BDUHCSBCVGXTJM-WUFINQPMSA-N

LogP

5.885800000000006

Topological Polar Surface Area

83.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

919

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

2-Piperazinone, 4-(((4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1H-imidazol-1-yl)carbonyl)-
BDUHCSBCVGXTJM-WUFINQPMSA-N
BCP9001003
53IA0V845C
(+)-Nutlin-3
Nutlin-3, (-)-
NSC756875
4-[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
NSC-756876
NSC-732664
4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone
SCHEMBL1155752
NSC-756875
SML-0580
675576-98-4
4j3e
BDBM50229787
4-(((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL)CARBONYL)PIPERAZIN-2-ONE
nutlin-3A
Q27166862
NSC763443
4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4, 5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CS-0296
C30H30Cl2N4O4
Nutlin3a
Z2037279564
Nutlin-3
EX-A1359
UNII-53IA0V845C

MDL Number

MFCD14636430

FAQ

What is Nutlin-3a (CAS: 675576-98-4)?

Nutlin-3a is a potent inhibitor of the transcriptional coactivator p300/CBP. It is a derivative of benzamide and is used primarily in research for studying the effects on the p53 pathway.

What are the main uses of Nutlin-3a (CAS: 675576-98-4)?

Nutlin-3a is mainly used in pharmaceutical and biochemical research to investigate the modulation of the p53 pathway. It is also used in cancer research to explore its potential as a therapeutic agent.

Is Nutlin-3a (CAS: 675576-98-4) safe?

Nutlin-3a is considered safe for use in controlled laboratory settings under proper safety protocols. However, it should be handled with care due to its potency and potential toxicity. Protective measures include wearing gloves, goggles, and a lab coat during handling.

How should Nutlin-3a (CAS: 675576-98-4) be stored?

Nutlin-3a should be stored in a cool, dry place, away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent degradation. Avoid storing it close to incompatible substances such as acids or oxidizers.