1H-Pyrazolo[3,4-b]pyridin-3-amine

Basic Information

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CAS Number

6752-16-5

Molecular Formula

C6H6N4

Molecular Weight

134.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

187-192 °C

Boiling Point

406.7℃ at 760 mmHg

Density

1.48 g/cm3

Flash Point

228.7℃

Refractive Index

1.806

SMILES

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C1=CC2=C(NN=C2N=C1)N

InChI

InChI=1S/C6H6N4/c7-5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H3,7,8,9,10)

InChIKey

LUAQTQAFUORQHV-UHFFFAOYSA-N

LogP

0.5400999999999998

Topological Polar Surface Area

67.59 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

127

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

CS-M2176
1h-pyrazol[3,4]pyridin-3-amine
FT-0600103
AM20061434
MFCD04113611
NSC-48665
NSC48665
3-aminopyrazolo[3,4-b]pyridine
3-Amino-7-azaindazole, 97%
A835790
Q-103493
AC-24355
2H-pyrazolo[3,4-b]pyridin-3-amine
(3R,4R)-tert-butyl3-amino-4-((2,5-dimethoxyphenylsulfonyl)methyl)pyrrolidine-1-carboxylate
2X-0703
1H-pyrazolo[3,4-b]pyridin-3-amine
G10019
AKOS006223902
1H-Pyrazolo[3,4-b]pyridin-3-ylamine
PB23388
EN300-26128
3-amino-1H-pyrazolopyridine
3-Amino-pyrazolo[3,4-b]pyridine
3-amino-2h-pyrazolo[3,4-b]pyridine
CS-0356764
SY007922
3-amino-1h-pyrazolo[3,4-b]pyridine
AKOS000320222
F3284-8132
6752-16-5
64781-70-0

MDL Number

MFCD04113611

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5)?

1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5) is a solid at room temperature with a molecular weight of approximately 168.16 g/mol. It has a solubility of about 1.5 mg/mL in water and poor solubility in common organic solvents. This compound is relatively stable but can react with strong acids and bases. It is often used in pharmaceuticals and sensors due to its unique chemical properties.

How is 1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5) typically synthesized?

1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5) can be synthesized via the reaction of 4-amino-1H-pyrazolo[3,4-b]pyridine with hydrazine hydrate. The process involves mild heating and yields a high purity product. The reaction is selective and provides a yield of about 85%. This method is widely used in the laboratory for the preparation of this compound.

What industries use 1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5)?

1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5) is primarily used in the pharmaceutical and sensor industries. It serves as a precursor in the synthesis of drugs and is also utilized in developing chemical sensors for detecting various analytes. Its unique chemical properties make it valuable in these applications.

What precautions should be taken when handling 1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5)?

When handling 1H-Pyrazolo[3,4-b]pyridin-3-amine (CAS: 6752-16-5), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to minimize inhalation. In case of a spill, immediately clean up using an appropriate absorbent material and dispose of it according to local regulations. Always consult the safety data sheet (SDS) for detailed handling instructions and emergency procedures.