1,3-Thiazole-2,4-diamine

Basic Information

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CAS Number

67355-26-4

Molecular Formula

C3H5N3S

Molecular Weight

115.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

340°C at 760 mmHg

Density

1.501

Flash Point

159.4°C

Refractive Index

1.748

SMILES

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C1=C(N=C(S1)N)N

InChI

InChI=1S/C3H5N3S/c4-2-1-7-3(5)6-2/h1H,4H2,(H2,5,6)

InChIKey

WKXCZMFWXZRMEZ-UHFFFAOYSA-N

LogP

0.3075000000000001

Topological Polar Surface Area

64.93 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

67.2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS009092919
diaminothiazole
67355-26-4
MFCD06738274
FT-0707053
1,3-thiazole-2,4-diamine
SCHEMBL461605
AB00987320-01
Thiazole-2,4-diamine
EN300-34721
BS-12711
F2145-0277
1,3-THIAZOLE-2,4-DIAMINE, HCL
1,3-Thiazole-2,4-diamine hydrochloride (1:1)
1,3-THIAZOLE-2,4-DIAMINE HYDROCHLORIDE
1,3-Thiazole-2,4-diamine, HCl,
2,4-Thiazolediamine
1,3-Thiazole-2,4-diaMine, HCl

MDL Number

MFCD06738274

FAQ

What are the physical and chemical properties of 1,3-Thiazole-2,4-diamine (CAS: 67355-26-4)?

1,3-Thiazole-2,4-diamine is a white or pale yellow crystalline solid with a molecular weight of approximately 132.16 g/mol. It is slightly soluble in water and ethanol. Chemically, it is a nitrogen-containing heterocyclic compound that shows basic properties and can react with various acids to form salts. It is also known for its reactivity towards nucleophiles and electrophiles.

How is 1,3-Thiazole-2,4-diamine (CAS: 67355-26-4) typically synthesized?

1,3-Thiazole-2,4-diamine is typically synthesized by the reaction of thiosemicarbazide with 1,3-thiazole in the presence of a base like sodium hydroxide. The reaction proceeds under reflux conditions, and the product is isolated by recrystallization from a suitable solvent. The method is known for its high yield and good selectivity.

What industries use 1,3-Thiazole-2,4-diamine (CAS: 67355-26-4)?

1,3-Thiazole-2,4-diamine finds applications in the pharmaceutical industry for the synthesis of drugs, as a precursor in organic synthesis, and in the production of certain polymers. It is also used in sensor technology and semiconductor manufacturing due to its chemical properties.

What precautions should be taken when handling 1,3-Thiazole-2,4-diamine (CAS: 67355-26-4)?

When handling 1,3-Thiazole-2,4-diamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials, and the area should be washed down with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.