(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

Basic Information

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CAS Number

67-73-2

Molecular Formula

C24H30F2O6

Molecular Weight

452.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

267-269 °C

Boiling Point

578.5°C at 760 mmHg

Density

1.1826 (estimate)

Water Solubility

Soluble in water (partly), DMSO, alcohol, chloroform and methanol.

Flash Point

304

Refractive Index

103 ° (C=1, MeOH)

Specific Rotation

D +95° (chloroform)

SMILES

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CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C

InChI

InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChIKey

FEBLZLNTKCEFIT-VSXGLTOVSA-N

LogP

2.366800000000001

Topological Polar Surface Area

93.06000000000002 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

960

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

PREGNA-1,4-DIENE-3,20-DIONE, 6,9-DIFLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (6.ALPHA.,11.BETA.,16.ALPHA.)-
EINECS 200-668-5
Synotic
Fluocinolone acetonide intravitreal implant
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Oto-synalar
FLUOCINOLONE ACETONIDE [MI]
6.alpha.,17-acetonide
Flucinolone acetonide
6alpha,9alpha-Difluoro-11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
Fluocinolone acetonide (JP17/USP/INN)
Synalar
flucinolone
(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
SR-01000000109
W-104704
DTXCID8020674
C24H30F2O6
FLUOCINOLONE ACETONIDE [INN]
Fluocinolone acetonide; 6?,9-Difluoro-11?,21-dihydroxy-16?,17-(1-methylethylidenedioxy)pregna-1,4-diene-3,20-dione
Prodermin
Fluocinolone acetonide [USAN:INN:JAN]
FLUOCINOLONE ACETONIDE COMPONENT OF NEO-SYNALAR
Acetonida de fluocinolona [INN-Spanish]
NEO-SYNALAR COMPONENT FLUOCINOLONE ACETONIDE
Dermatin
4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Tox21_110869_1
MLS001076276
Fluocinolone acetonide (JP15/USP/INN)

MDL Number

MFCD00010525

Customs Code

2937210000

FAQ

What is (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (CAS: 67-73-2)?

This is a complex organic compound with the CAS number 67-73-2. It features a dioxol ring system, multiple hydroxyl and glycoloyl groups, and several methyl substituents. The molecule exhibits stereoisomerism due to its chiral centers and is characterized by its fluorinated structure, which may influence reactivity and biological activity.

What are the main uses of (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (CAS: 67-73-2)?

This compound is primarily used in pharmaceutical research as a structural analog or intermediate in drug development. Its unique fluorinated and glycoloyl groups may contribute to applications in medicinal chemistry, such as targeting specific biological pathways. It is also studied in organic synthesis for its complex ring systems and stereochemistry.

Is (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (CAS: 67-73-2) safe?

Safety data for this compound is limited, but as a synthetic organic compound, it may require caution during handling. It is advisable to follow standard laboratory safety protocols, use personal protective equipment (PPE), and consult safety data sheets (SDS) for specific guidelines. Its potential toxicity and reactivity should be evaluated based on empirical studies and regulatory standards.

How should (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one (CAS: 67-73-2) be stored?

Store this compound in a sealed, cool, and dry container, away from light and moisture. It should be kept at a temperature below 25°C and in a controlled humidity environment to maintain stability. Avoid exposure to incompatible chemicals and ensure proper ventilation in storage areas to prevent degradation or hazards.