Nitrofurantoin | CAS No. 67-20-9

Q: What is Nitrofurantoin (CAS: 67-20-9)?

Nitrofurantoin is an antibiotic medication used primarily to treat urinary tract infections. It has the chemical formula C11H11N3O5S and is known for its broad-spectrum antibacterial activity. The compound is a yellowish solid at room temperature and is commonly available in various dosage forms, including tablets and capsules.

Q: What are the main uses of Nitrofurantoin (CAS: 67-20-9)?

Nitrofurantoin is mainly used in the treatment of urinary tract infections (UTIs) caused by susceptible bacteria. It is also utilized in research for studying antimicrobial properties and in some industrial applications. Due to its effectiveness against gram-positive and gram-negative bacteria, it remains a key medication in pharmaceutical settings for lower urinary tract infections.

Q: Is Nitrofurantoin (CAS: 67-20-9) safe?

Nitrofurantoin is generally considered safe when used as directed, but it may cause side effects such as gastrointestinal discomfort or allergic reactions. Proper handling and adherence to safety guidelines are essential to minimize risks. It is important to follow medical advice and safety standards to ensure its safe use in both humans and animals.

Q: How should Nitrofurantoin (CAS: 67-20-9) be stored?

Nitrofurantoin should be stored in a cool, dry place away from direct sunlight. It is best kept in a sealed container at a temperature between 15°C to 30°C and with low humidity. Avoid exposure to moisture and light to maintain its stability and effectiveness over time.

Nitrofurantoin

Basic Information

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CAS Number

67-20-9

Molecular Formula

C8H6N4O5

Molecular Weight

238.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

268°C(dec.)

Boiling Point

380.75°C (rough estimate)

Density

1.5824 (rough estimate)

Water Solubility

<0.01 g/100 mL at 19 ºC

Flash Point

Solubility

DMF: soluble50mg/mL

Refractive Index

1.6700 (estimate)

Odor

ODORLESS

SMILES

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C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]

InChI

InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+

InChIKey

NXFQHRVNIOXGAQ-YCRREMRBSA-N

LogP

log Kow= -0.47

pKa

7.2(at 25℃)

Complexity

390

Safety Information

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GHS Hazard Pictograms

H302

H334

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

Hazard Class

Class 6.1(b) Class 6.1(b)

Stability

Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong alkalies, strong acids. Decomposes upon contact with most metals other than stainless steel and aluminium.

Sensitiveness

Light Sensitive & Hygroscopic

Synonyms & References

English

2,4-imidazolidinadiona, 1-[[(5-nitro-2-furanil) metilen] amino]-
Macrobid (TN)
NITROFURANTOIN [VANDF]
J01XE01
EINECS 200-646-5
DTXSID7020972
1-{[(5-nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione
Cyantin
AB00052052_03
178170-37-1
NITROFURANTOIN [MI]
NCGC00091505-04
Urantoin (TN)
1-(((5-nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione
NITROFURANTOIN [JAN]
AKOS001678301
N-(5-Nitro-2-furfurylidine)-1-aminohydantoin; N-(5-Nitrofurfurylidene)-1aminohydantoin
67-20-9
Ro-Antoin
CCRIS 1192
Urolong
Uerineks
NXFQHRVNIOXGAQ-YCRREMRBSA-N
LS-1560
s4536
C8-H6-N4-O5
SMR000058271
1-[(E)-(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione
N-(5-Nitrofurfurylidene)-1-aminohydantoin
Alfuran
NSC-2107

MDL Number

MFCD00003224

Customs Code

2933990090

FAQ

What is Nitrofurantoin (CAS: 67-20-9)?

Nitrofurantoin is an antibiotic medication used primarily to treat urinary tract infections. It has the chemical formula C11H11N3O5S and is known for its broad-spectrum antibacterial activity. The compound is a yellowish solid at room temperature and is commonly available in various dosage forms, including tablets and capsules.

What are the main uses of Nitrofurantoin (CAS: 67-20-9)?

Nitrofurantoin is mainly used in the treatment of urinary tract infections (UTIs) caused by susceptible bacteria. It is also utilized in research for studying antimicrobial properties and in some industrial applications. Due to its effectiveness against gram-positive and gram-negative bacteria, it remains a key medication in pharmaceutical settings for lower urinary tract infections.

Is Nitrofurantoin (CAS: 67-20-9) safe?

Nitrofurantoin is generally considered safe when used as directed, but it may cause side effects such as gastrointestinal discomfort or allergic reactions. Proper handling and adherence to safety guidelines are essential to minimize risks. It is important to follow medical advice and safety standards to ensure its safe use in both humans and animals.

How should Nitrofurantoin (CAS: 67-20-9) be stored?

Nitrofurantoin should be stored in a cool, dry place away from direct sunlight. It is best kept in a sealed container at a temperature between 15°C to 30°C and with low humidity. Avoid exposure to moisture and light to maintain its stability and effectiveness over time.