E-64 | CAS No. 66701-25-5

E-64

Basic Information

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CAS Number

66701-25-5

Molecular Formula

C15H27N5O5

Molecular Weight

357.41 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

No data available

Boiling Point

No data available

Density

1.4400

Water Solubility

Soluble in DMSO (25mg/ml), or water (20mg/ml)

Flash Point

No data available

Solubility

H2O: 20 mg/mL, clear, colorless

Refractive Index

1.617

SMILES

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CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O

InChI

InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1

InChIKey

LTLYEAJONXGNFG-DCAQKATOSA-N

LogP

-1.460899999999994

Topological Polar Surface Area

172.42999999999998 Å²

Hydrogen Bond Donor/Acceptor

7 / 10

Complexity

518

Safety Information

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Sensitiveness

Light Sensitive

Synonyms & References

English

(2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
(2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
(2S,3S)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid
E 64
C01341
e-64
SCHEMBL4740187
CHEBI:30270
MFCD00080261
CS-4140
Q5321373
(2S,3S)-3-[[(1S)-1-(4-guanidinobutylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylic acid
5-18-07-00006 (Beilstein Handbook Reference)
BDBM50157741
3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid
E-0010
(2S,3S)-3-(N-{(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl}carbamoyl)oxirane-2-carboxylic acid
(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid
2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
trans-epoxysuccinyl-l-leucylamido-(4-guanidino)butane
HY-15282
Thiol protease inhibitor
BRN 1405664
E 64 (proteinase inhibitor)
R76F7856MV
66701-25-5
CHEMBL374508
CCG-208198
FD21944
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE
CCG-207844

MDL Number

MFCD07366493

FAQ

What regulatory guidelines apply to E-64 (CAS: 66701-25-5)?

E-64 (CAS: 66701-25-5) is subject to various regulatory guidelines, including the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for hazard communication. It is also regulated by REACH in the European Union, which requires suppliers to conduct risk assessments and register substances above a certain tonnage. In the United States, the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) may have specific requirements for handling and use. Always consult the latest regulatory documents and safety data sheets (SDS) for detailed information.

Are there alternatives to E-64 in synthesis (CAS: 66701-25-5)?

There are several alternatives to E-64 (CAS: 66701-25-5) in synthesis, including isoxazole derivatives and other thiazole compounds. These alternatives can serve similar functions in certain chemical reactions. Researchers often choose alternatives based on availability, cost, and specific reaction requirements. Commonly used isomers and analogs include those with different functional groups or substituents.

What is the market or research trend for E-64 (CAS: 66701-25-5)?

The market trend for E-64 (CAS: 66701-25-5) is largely driven by its applications in cell biology research, particularly in the inhibition of proteasome activity. Recent research trends focus on understanding its mechanism of action and exploring its use in drug discovery. Market trends show increasing interest and demand, especially in the biotech and pharmaceutical industries. Price trends are generally positive, reflecting its value in research and development.

How should waste containing E-64 (CAS: 66701-25-5) be handled?

Waste containing E-64 (CAS: 66701-25-5) should be managed in accordance with local and international environmental regulations. Proper collection and storage of waste is crucial, and it is often recommended to work with certified waste management professionals. For waste disposal, options include incineration, chemical treatment, or landfilling, depending on the local regulations and the nature of the waste. Always ensure that all handling and disposal procedures are documented and follow safety protocols to prevent environmental contamination.