2-Chloro-3-pyridinol

Basic Information

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CAS Number

6636-78-8

Molecular Formula

C5H4ClNO

Molecular Weight

129.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

167.0 to 172.0 deg-C

Boiling Point

316.2℃ at 760 mmHg

Density

1.2309 (rough estimate)

Flash Point

145℃

Refractive Index

1.4510 (estimate)

SMILES

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C1=CC(=C(N=C1)Cl)O

InChI

InChI=1S/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H

InChIKey

RSOPTYAZDFSMTN-UHFFFAOYSA-N

LogP

1.4405999999999999

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

78.8

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

PS-4577
SY001399
WLN: T6NJ BG CQ
2-Chloro-3-hydroxypyridine (2-Chloro-3-pyridinol)
InChI=1/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H
CS-D0978
HY-32833
Q27292085
2-Chloropyridin-3-ol
AI3-61989
PB21615
NSC-18469
DTXSID3022243
AM20061429
SCHEMBL188902
BP-12768
NSC 18469
2-Chloro-3-hydroxypyridine, 98%
5-21-02-00085 (Beilstein Handbook Reference)
EN300-80718
6636-78-8
2-Chloro-3-hydroxypyridine
3-Pyridinol, 2-chloro-
2-chloro-pyridin-3-ol
CHEMBL4636200
A8956
2-Chloro-3-pyridinol
BB 0219900
AC-4666
FT-0602427
AKOS000431571

MDL Number

MFCD00006235

Customs Code

2933399090

FAQ

What is 2-Chloro-3-pyridinol (CAS: 6636-78-8)?

2-Chloro-3-pyridinol (CAS: 6636-78-8) is a heterocyclic organic compound with the chemical formula C5H5ClNO. It features a pyridine ring substituted with a hydroxyl group at position 3 and a chlorine atom at position 2. This compound is known for its aromatic structure and is commonly used as an intermediate in chemical synthesis. Its physical properties include a solid state at room temperature and moderate solubility in polar solvents.

What are the main uses of 2-Chloro-3-pyridinol (CAS: 6636-78-8)?

2-Chloro-3-pyridinol (CAS: 6636-78-8) is primarily used in pharmaceuticals as a precursor for synthesizing antifungal and antibiotic drugs. It also finds applications in industrial chemistry for producing dyes and pesticides, and in research for organic reactions involving pyridine derivatives. Its versatility makes it a key compound in chemical manufacturing processes.

Is 2-Chloro-3-pyridinol (CAS: 6636-78-8) safe?

2-Chloro-3-pyridinol (CAS: 6636-78-8) requires careful handling due to potential toxicity. It is classified as a hazardous substance with an LD50 value of 300 mg/kg in rats. Safety precautions include wearing gloves, goggles, and a lab coat, as well as ensuring proper ventilation. Adherence to OSHA and EPA guidelines is essential to minimize health and environmental risks.

How should 2-Chloro-3-pyridinol (CAS: 6636-78-8) be stored?

2-Chloro-3-pyridinol (CAS: 6636-78-8) should be stored in a cool, dry place (ideally 2-8°C), away from light and moisture. Use airtight, sealed containers made of glass or plastic to maintain stability. Avoid exposure to air and heat to prevent degradation, and ensure storage areas are well-ventilated to mitigate potential fumes.