Cefotiam hydrochloride

Basic Information

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CAS Number

66309-69-1

Molecular Formula

C18H25Cl2N9O4S3

Molecular Weight

598.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

940°C at 760 mmHg

Water Solubility

Soluble in water

Flash Point

>110°(230°F)

Solubility

H2O: ≥22M

SMILES

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CN(C)CCN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O.Cl.Cl

InChI

InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1

InChIKey

BWRRTAXZCKVRON-DGPOFWGLSA-N

LogP

0.1903999999999999

Topological Polar Surface Area

172.45999999999998 Å²

Hydrogen Bond Donor/Acceptor

4 / 13

Complexity

848

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

CS-4846
SCE-963 hydrochloride
D01819
CCG-270193
5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-((2-(2-AMINO-4-THIAZOLYL)ACETYL)AMINO)-3-(((1-(2-(DIMETHYLAMINO)ETHYL)-1H-TETRAZOL-5-YL)THIO)METHYL)-8-OXO-, HYDROCHLORIDE (1:2), (6R,7R)-
7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid dihydrochloride
Ceradon
(6R,7R)-7-[2-(2-Amino-4-thiazolyl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, dihydrochloride, (6R-trans)-
CEFOTIAM HYDROCHLORIDE (USP-RS)
Abbott-48999
Cefotiam dihydrochloride
CEFOTIAM HYDROCHLORIDE [USAN]
s5005
Ceradon (TN)
Cefotiam hydrochloride (JP17/USP)
Pansporin Ampullen
CEFOTIAM HYDROCHLORIDE [MART.]
SCHEMBL193845
Q27114289
CEFOTIAM HYDROCHLORIDE (MART.)
SCE-963
SCHEMBL11450011
NSC 758164
(6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetylamino)-3-(1-(2-dimethylaminoethyl)-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid dihydrochloride
Cefotiam (hydrochloride)
CEFOTIAM HYDROCHLORIDE [JAN]
CEFOTIAM HYDROCHLORIDE
CEFOTIAM DIHYDROCHLORIDE [MI]
CGP-14221/E
(6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride

MDL Number

MFCD01682052

FAQ

What regulatory guidelines apply to Cefotiam hydrochloride (CAS: 66309-69-1)?

Cefotiam hydrochloride (CAS: 66309-69-1) falls under the regulatory guidelines of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for health hazards. It is also subject to the REACH regulations in the European Union, which require registration of chemicals above a certain tonnage threshold. In the U.S., the FDA regulates its use in pharmaceuticals, and the EPA oversees environmental concerns. Compliance with these regulations is essential for its safe handling and use.

Are there alternatives to Cefotiam hydrochloride (CAS: 66309-69-1) in synthesis?

There are alternatives to Cefotiam hydrochloride (CAS: 66309-69-1) in synthesis, such as other cephalosporins like cefalexin and cefazolin. These alternatives offer similar antibiotic properties and can be used as substitutes depending on the specific requirements of the synthesis process. Additionally, researchers often explore new synthetic pathways and reagents to improve yield and reduce environmental impact.

What is the market or research trend for Cefotiam hydrochloride (CAS: 66309-69-1)?

The market for Cefotiam hydrochloride (CAS: 66309-69-1) reflects growing demand in the pharmaceutical industry, particularly for broad-spectrum antibiotics. Research trends focus on understanding its pharmacokinetics, dosing regimens, and potential resistance. Market trends show a steady demand, with innovations in drug delivery systems and combination therapies driving growth. Emerging research also explores its use in treating various bacterial infections, including those resistant to other antibiotics.

How should waste containing Cefotiam hydrochloride (CAS: 66309-69-1) be handled?

Waste containing Cefotiam hydrochloride (CAS: 66309-69-1) should be collected in appropriate containers and stored safely to prevent environmental contamination. Incineration is a common disposal method, ensuring complete destruction of the compound. Professional waste disposal services are recommended for handling the waste to ensure compliance with environmental regulations. Proper training and safety precautions must be observed during the handling and disposal process to avoid environmental hazards.