(2R)-3-Amino-1,2-propanediol

Basic Information

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CAS Number

66211-46-9

Molecular Formula

C3H9NO2

Molecular Weight

91.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Physical State

Solid

Melting Point

52.0 to 59.0 deg-C

Boiling Point

163°C/15mmHg

Density

1.181

Refractive Index

n20/D 1.483(lit.)

Specific Rotation

+25 ~ +30°(c=4, 5M HCl)

SMILES

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C(C(CO)O)N

InChI

InChI=1S/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2/t3-/m1/s1

InChIKey

KQIGMPWTAHJUMN-GSVOUGTGSA-N

LogP

-1.7017

Topological Polar Surface Area

66.48 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

Safety Information

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GHS Hazard Pictograms

H302

H314

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

(R)-3-Amino-1,2-propanediol
(R)-(+)-Amino-1,2-propanediol
CS-W002683
66211-46-9
AKOS005259374
EN300-92384
(2R)-3-aminopropane-1,2-diol
KQIGMPWTAHJUMN-GSVOUGTGSA-N
3-amino-(2R)-1,2-propanediol
(2R)-3-amino-1,2-propanediol
Q56224049
(R)-(+)-3-Amino-1,2-propandiol
(R)-3-Amino-1,2-propanediol, >=98.0% (T)
AM20100602
1,2-Propanediol, 3-amino-, (2R)-
(R)-3-amino-propane-1,2-diol
MFCD00798261
C3H9NO2
AS-14147
(R)-3-aminopropane-1,2-diol
(r)-(+)-3-amino-1,2-propanediol
AC-7033
AKOS006339503
A8939
(R)-2,3-Dihydroxypropan-1-amine
(R)-(+)-3-amino-1, 2-propanediol
SY008127
((R)-2,3-Dihydroxypropyl)amine
(R)-3-Aminopropane-1,2-diol
R-3-Amino-1,2-propanediol
(R)-(+)-3-AMINO-1,2-PROPANEDIOL

MDL Number

MFCD00798261

Customs Code

2922199090

FAQ

What are the physical and chemical properties of (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9)?

The (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9) is a colorless, viscous liquid with a molecular weight of 107.12 g/mol. It has a specific gravity of 1.09 g/cm³ and a boiling point of 266.2°C. It is soluble in water and alcohols. It is known to react with acids to form salts and with aldehydes to form acylated derivatives. It is also reactive towards nucleophilic substitution reactions.

How is (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9) typically synthesized?

(2R)-3-Amino-1,2-propanediol can be synthesized by the reduction of 3-chloro-1,2-propanediol using a strong reducing agent like sodium borohydride. Alternatively, it can be prepared through hydrogenation of 1,3-propanedione, followed by reduction and amination. The reaction conditions include the use of a catalyst such as palladium on carbon and a base like sodium hydroxide.

What industries use (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9)?

(2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9) is widely used in the pharmaceutical industry for the synthesis of drug intermediates and as a precursor in the production of polymers and sensors. It is also utilized in the formulation of adhesives and sealants, as well as in the production of semiconductors and electronic materials.

What precautions should be taken when handling (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9)?

When handling (2R)-3-Amino-1,2-propanediol (CAS: 66211-46-9), ensure the use of proper personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. Store it in a fume hood or a well-ventilated area to avoid inhalation of fumes. In case of spillage, neutralize with a weak acid or base before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and emergency procedures.