5-Methyl-2-pyridinesulfonamide

Basic Information

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CAS Number

65938-77-4

Molecular Formula

C6H8N2O2S

Molecular Weight

172.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

127-132 °C

Density

1.346

Flash Point

172.3℃

Refractive Index

1.564

SMILES

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Cc1ccc(nc1)S(=O)(=O)N

InChI

InChI=1S/C6H8N2O2S/c1-5-2-3-6(8-4-5)11(7,9)10/h2-4H,1H3,(H2,7,9,10)

InChIKey

HXURYNQXMBRJLU-UHFFFAOYSA-N

LogP

0.03742000000000012

Topological Polar Surface Area

73.05 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

219

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5-Methyl-2-pyridinesulfonamide
5-Methyl-2-pyridines
5-Methylpyridine-2-sulfonamide
5-methyl-pyridine-2-sulfonamide
5-methyl-pyridine-2-sulphonamide
p-methyl-2-pyridinylsulfonylamide
2-Pyridinesulfonamide, 5-methyl-
PubChem23672
5-methyl-2-pyridinesulphonamide
HXURYNQXMBRJLU-UHFFFAOYSA-N
TRA0075106
VP13234
RP23459
SY014673
ST2418819
AB0026110
AM200

MDL Number

MFCD00661363

Customs Code

2935009090

FAQ

What are the physical and chemical properties of 5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4)?

5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4) is a white crystalline solid with a molecular weight of approximately 176.18 g/mol. It has a high solubility in organic solvents such as ethanol and poor solubility in water. This compound is relatively stable under normal conditions but can react with strong bases. It is used in various applications due to its unique chemical properties.

How is 5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4) typically synthesized?

5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4) is typically synthesized through the reaction of 5-methyl-2-pyridinecarboxaldehyde with sodium sulfite in the presence of a base. The reaction involves the condensation of the aldehyde with the sulfite to form the desired amide. The process yields a high purity product with good selectivity and yield.

What industries use 5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4)?

5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4) is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various drugs and as a functional group in polymer chemistry. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4)?

When handling 5-Methyl-2-pyridinesulfonamide (CAS: 65938-77-4), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. Ensure the use of a fume hood during the handling and synthesis of the compound to minimize inhalation risk. In case of a spill, immediately clean up using appropriate absorbents and dispose of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage instructions.